COVID-19 Outliers: Lessons to Better Understand SARS-CoV-2 Behaviour

Purpose: COVID-19 has become a global epidemic with more than 6 million active cases worldwide. This is a huge number even when the active cases have started to decrease in most of the developed world and the threat is looming of a second wave. The question is where the second wave would come from? Method: Our hypothesis is that the answer lies in the COVID-19 outliers. In most epidemiological and clinical studies, focus is on the patients who represent the majority population however, there is every likelihood that re-emergence of the virus will be the from the cases that are unique and not following the norm. Results and Conclusion: This may allow us to understand the behavior of SARS-CoV-2 better and allow us to hypothesize better about its biology. This paper analyzes 6 such COVID-19 patients reported by different regional Centers for Disease Control in China, which should be considered with regards to further spread and developing effective control of SARS-CoV2 epidemic.