Desorption electrospray ionisation mass spectrometry and tandem mass spectrometry of low molecular weight synthetic polymers

Anthony T. Jackson, Jonathan P. Williams, James Scrivens

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Abstract

    A range of low molecular weight synthetic polymers has been characterised by means of desorption electrospray ionisation (DESI) combined with both mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Accurate mass experiments were used to aid the structural determination of some of the oligomeric materials. The polymers analysed were poly(ethylene glycol) (PEG), polypropylene glycol (PPG), poly(methyl methacrylate) (PMMA) and poly(α-methyl styrene). An application of the technique for characterisation of a polymer used as part of an active ingredient in a pharmaceutical tablet is described. The mass spectra and tandem mass spectra of all of the polymers were obtained in seconds, indicating the sensitivity of the technique.

    Original languageEnglish
    Pages (from-to)2717-2727
    Number of pages11
    JournalRapid Communications in Mass Spectrometry
    Volume20
    Issue number18
    DOIs
    Publication statusPublished - 9 Oct 2006

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