Determining the preferred liquid reward in adult C57BL/6 mice

Using food rewards to motivate mice is common place in behavioural research. Using a reward which is highly desirable is of benefit as it can reduce the need to food restrict animals and can encourage higher levels of consumption, allowing for changes in levels of consumption following an intervention to be easily determined. Here, we aimed to determine the preferred milk reward for adult male C57Bl/6 mice. Thirty male C57Bl/6 mice were provided with either soya milk, chocolate milk, almond milk or water for a 4-hour period in a cross over design. When planning studies that involve the use of a palatable liquid reward, Soya milk is the preferred option for adult male C57BL/6 mice. Providing a liquid reward of high value will give increased levels of consumption with little or no food restriction required.