Abstract
Hypothesis / aims of study
Nitric oxide (NO) is known to be released from nerves and urothelium in urinary bladder, but its role has not been well established.
c-Kit antigen expressing interstitial cells (ICs) in the bladder are considered to be targets of NO, and consequently may modulate
the contractility of the detrusor. Examining the relationship between NO and ICs, and their function in the bladder, may help us to
understand the pathophysiology of bladder dysfunction. Therefore, we aim to localize the immunoreactivity of neuronal nitric oxide
synthase (nNOS), endothelial nitric oxide synthase (eNOS) and c-Kit in the mouse bladder, and investigate the function of NO and
ICs in the spontaneous activity of urothelium-intact and -removed detrusor preparations from nNOS knockout (nNOS-/-
) and sibling
control (nNOS+/+) mice.
Nitric oxide (NO) is known to be released from nerves and urothelium in urinary bladder, but its role has not been well established.
c-Kit antigen expressing interstitial cells (ICs) in the bladder are considered to be targets of NO, and consequently may modulate
the contractility of the detrusor. Examining the relationship between NO and ICs, and their function in the bladder, may help us to
understand the pathophysiology of bladder dysfunction. Therefore, we aim to localize the immunoreactivity of neuronal nitric oxide
synthase (nNOS), endothelial nitric oxide synthase (eNOS) and c-Kit in the mouse bladder, and investigate the function of NO and
ICs in the spontaneous activity of urothelium-intact and -removed detrusor preparations from nNOS knockout (nNOS-/-
) and sibling
control (nNOS+/+) mice.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 22 Oct 2008 |
| Externally published | Yes |
| Event | 38th Annual Meeting of the ICS: Mother of the World - Cairo, Egypt Duration: 20 Oct 2008 → 24 Oct 2008 |
Conference
| Conference | 38th Annual Meeting of the ICS |
|---|---|
| Abbreviated title | ICS 2008 |
| Country/Territory | Egypt |
| City | Cairo |
| Period | 20/10/08 → 24/10/08 |