Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling

Keyphrases

• Leishmania 100%
• Druggability 100%
• Serine Protease 100%
• Activity-based Protein Profiling 100%
• Antileishmanial Drugs 40%
• Serine Hydrolase 40%
• Current Treatment 20%
• High Cost 20%
• Mass Spectrometry Analysis 20%
• Active Sites 20%
• Drug Discovery 20%
• Leishmania Species 20%
• Leishmaniasis 20%
• New Drug Targets 20%
• Parasitic Protozoa 20%
• Drug Target 20%
• Rhodamine B (Rh B) 20%
• Quantitative Proteomics 20%
• Serine Protease Inhibitor 20%
• Expression Level 20%
• New Mechanisms of Action 20%
• Leishmania Mexicana 20%
• Genetic Method 20%
• Target Validation 20%
• Leishmania Parasites 20%
• ITRAQ 20%
• Profiling Method 20%
• Target Identification 20%
• Lactacystin 20%
• Prolyl Oligopeptidase 20%
• Site-directed 20%
• New Agents 20%
• Carboxypeptidase 20%
• Efficacy-toxicity 20%
• Fluorophosphonate 20%
• Biotin 20%
• Chymostatin 20%
• Selective Inhibition 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Leishmania 100%
• Serine Proteinase 100%
• Disease 28%
• Serine 28%
• Hydrolase 28%
• Leishmaniasis 14%
• Protozoon 14%
• Drug Discovery 14%
• Leishmania mexicana 14%
• Target Identification 14%
• Prolyl Endopeptidase 14%
• Lactacystin 14%
• Chymostatin 14%
• Rhodamine 14%
• Fluorophosphonic Acid Derivative 14%
• Serine Proteinase Inhibitor 14%
• Carboxypeptidase 14%
• Biotin 14%

Immunology and Microbiology

• Leishmania 100%
• Protozoa 14%
• Life Cycle 14%
• Leishmaniasis 14%
• Leishmania mexicana 14%
• Oligopeptidase 14%
• DNA Template 14%
• Parasitology 14%