Early and late reactions following the use of iopamidol 340, iomeprol 350 and iodixanol 320 in cardiac catheterization

A. G.C. Sutton, P. Finn, P. G. Campbell, D. J.A. Price, J. A. Hall, M. J. Stewart, A. Davies, N. J. Linker, A. A. Harcombe, M. A. De Belder

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31 Citations (Scopus)


Goal. To investigate the incidence of early (< 24 hours) and late (> 24 hours to 7 days) reactions to 3 contrast agents commonly used in cardiac catheterization. Methods and Results. A total of 2,108 patients undergoing cardiac catheterization in a Regional Cardiothoracic Unit were randomly assigned to receive 1 of 3 commonly used contrast agents in a prospective, double-blind study. The contrast agents were iopamidol 340 (Niopam®), a nonionic monomer; iomeprol 350 (Iomeron®), a nonionic dimer; and iodixanol 320 (Visipaque®), a nonionic dimer. The main outcome measures were the incidence of early (< 24 hours) reactions following catheterization and the incidence of late (24 hours to 7 days) reactions. Early reactions, excluding patients with heat on left ventriculography as the sole symptom, were relatively common (7.4%), but there was no significant difference between the 3 agents (p = 0.35). Late skin reactions, excluding reactions solely at the site of the arterial puncture and continuations of early urticarial reactions, were also relatively common (5.4%), but the incidence differed between the 3 agents. Such reactions occurred in 2.7% of those receiving iopamidol 340 (Niopam®), 3.5% of those receiving iomeprol 350 (Iomeron®) and 10.4% of those receiving iodixanol 320 (Visipaque®) (p < 0.01). Conclusion. The incidence of early adverse reactions is similar with these 3 contrast agents. However, late skin reactions are significantly more common with iodixanol 320 (Visipaque®) than with the other 2 agents. Although such reactions were rarely troublesome, patients should be advised accordingly.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Invasive Cardiology
Issue number3
Publication statusPublished - 1 Mar 2003


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