Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride

Sandra L. Amaral, Liane B. Azevedo, Marilia A.R. Buzalaf, Mayara F. Fabricio, Mileni S. Fernandes, Ruth A. Valentine, Anne Maguire, Fatemeh Zohoori

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Abstract

The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.

Original languageEnglish
Article number3211
Number of pages7
JournalScientific Reports
Volume8
Early online date16 Feb 2018
DOIs
Publication statusPublished - 16 Feb 2018

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Fluorides
Bone and Bones
Body Weight

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Amaral, S. L., Azevedo, L. B., Buzalaf, M. A. R., Fabricio, M. F., Fernandes, M. S., Valentine, R. A., ... Zohoori, F. (2018). Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride. Scientific Reports, 8, [3211]. https://doi.org/10.1038/s41598-018-21616-2
Amaral, Sandra L. ; Azevedo, Liane B. ; Buzalaf, Marilia A.R. ; Fabricio, Mayara F. ; Fernandes, Mileni S. ; Valentine, Ruth A. ; Maguire, Anne ; Zohoori, Fatemeh . / Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride. In: Scientific Reports. 2018 ; Vol. 8.
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abstract = "The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.",
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Amaral, SL, Azevedo, LB, Buzalaf, MAR, Fabricio, MF, Fernandes, MS, Valentine, RA, Maguire, A & Zohoori, F 2018, 'Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride', Scientific Reports, vol. 8, 3211. https://doi.org/10.1038/s41598-018-21616-2

Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride. / Amaral, Sandra L.; Azevedo, Liane B.; Buzalaf, Marilia A.R.; Fabricio, Mayara F.; Fernandes, Mileni S.; Valentine, Ruth A.; Maguire, Anne; Zohoori, Fatemeh .

In: Scientific Reports, Vol. 8, 3211, 16.02.2018.

Research output: Contribution to journalArticle

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T1 - Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride

AU - Amaral, Sandra L.

AU - Azevedo, Liane B.

AU - Buzalaf, Marilia A.R.

AU - Fabricio, Mayara F.

AU - Fernandes, Mileni S.

AU - Valentine, Ruth A.

AU - Maguire, Anne

AU - Zohoori, Fatemeh

PY - 2018/2/16

Y1 - 2018/2/16

N2 - The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.

AB - The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.

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