TY - JOUR
T1 - Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride
AU - Amaral, Sandra L.
AU - Azevedo, Liane B.
AU - Buzalaf, Marilia A.R.
AU - Fabricio, Mayara F.
AU - Fernandes, Mileni S.
AU - Valentine, Ruth A.
AU - Maguire, Anne
AU - Zohoori, Fatemeh
PY - 2018/2/16
Y1 - 2018/2/16
N2 - The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.
AB - The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.
UR - http://www.mendeley.com/research/effect-chronic-exercise-fluoride-metabolism-fluorosissusceptible-mice-exposed-high-fluoride
U2 - 10.1038/s41598-018-21616-2
DO - 10.1038/s41598-018-21616-2
M3 - Article
AN - SCOPUS:85042211242
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
M1 - 3211
ER -
