Effect of Exercise on Fluoride Metabolism in Adult Humans

Research output: Contribution to conferenceAbstract

Abstract

The effect of exercise on fluoride metabolism in humans is unknown. This pilot study aimed to investigate the effect of exercise on fluoride ingestion and excretion in adults
Objective: To measure urinary fluoride excretion (UFE) and plasma fluoride concentration (plasma-F) following no exercise (control) and three exercise conditions.
Methods: In a 4-treatment, 4-period cross-over pilot-trial, 9 healthy volunteers aged 20-35y living in a non-fluoridated area underwent a 2-week “wash-out” with non-fluoridated toothpaste. Prior to each of four different acute conditions separated by one week, with order assigned using a Latin square, participants were given a 1-mg fluoride tablet. The exercise was performed on a stationary bike with the intensity determined by the category-ratio rating scale of perceived exertion (RPE): none (control), light (RPE–3), moderate (RPE–5) and vigorous (RPE-7). Blood and urine samples were taken before (baseline) and after exercise and changes in UFE and plasma-F were measured. Data were analysed using a linear mixed model, adjusting for baseline (pre-exercise) value and any period effect. The mean (95% CI) difference in UFE and plasma-F after each exercise regime was determined.
Results: Mean (SD) age of the participants was 25.3 (3.5) y. Mean baseline-adjusted plasma-F was 8, 10, 15 and 10 ng/ml for control, light, moderate and vigorous exercise, respectively. The effect of moderate exercise vs. control on plasma-F was 7 (-6 to 19) ng/ml. Mean baseline-adjusted UFE was 59, 58, 45 and 48 µg/h for control, light, moderate and vigorous exercise, respectively. Moderate exercise resulted in a lower mean baseline-adjusted UFE in comparison with control (mean difference -14; -2 to -25 µg/h).
Conclusion: Exercise appears to have no substantial effect on fluoride absorption; however, moderate exercise may reduce fluoride excretion and consequently increase fluoride retention in the body. A larger definitive trial is needed to confirm these findings.
Original languageEnglish
Publication statusPublished - 2014
EventInternational Association for Dental Research Congress 2014 - Dubrovnik, Croatia
Duration: 10 Sep 201414 Sep 2014
https://www.iadr.org/IADR/Meetings/Past-Meetings

Conference

ConferenceInternational Association for Dental Research Congress 2014
CountryCroatia
Period10/09/1414/09/14
Internet address

Fingerprint

Fluorides
Exercise
Light
Toothpastes
Cross-Over Studies
Tablets
Linear Models
Healthy Volunteers

Cite this

Innerd, A. (2014). Effect of Exercise on Fluoride Metabolism in Adult Humans. Abstract from International Association for Dental Research Congress 2014, Croatia.
Innerd, Alison. / Effect of Exercise on Fluoride Metabolism in Adult Humans. Abstract from International Association for Dental Research Congress 2014, Croatia.
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title = "Effect of Exercise on Fluoride Metabolism in Adult Humans",
abstract = "The effect of exercise on fluoride metabolism in humans is unknown. This pilot study aimed to investigate the effect of exercise on fluoride ingestion and excretion in adults Objective: To measure urinary fluoride excretion (UFE) and plasma fluoride concentration (plasma-F) following no exercise (control) and three exercise conditions. Methods: In a 4-treatment, 4-period cross-over pilot-trial, 9 healthy volunteers aged 20-35y living in a non-fluoridated area underwent a 2-week “wash-out” with non-fluoridated toothpaste. Prior to each of four different acute conditions separated by one week, with order assigned using a Latin square, participants were given a 1-mg fluoride tablet. The exercise was performed on a stationary bike with the intensity determined by the category-ratio rating scale of perceived exertion (RPE): none (control), light (RPE–3), moderate (RPE–5) and vigorous (RPE-7). Blood and urine samples were taken before (baseline) and after exercise and changes in UFE and plasma-F were measured. Data were analysed using a linear mixed model, adjusting for baseline (pre-exercise) value and any period effect. The mean (95{\%} CI) difference in UFE and plasma-F after each exercise regime was determined. Results: Mean (SD) age of the participants was 25.3 (3.5) y. Mean baseline-adjusted plasma-F was 8, 10, 15 and 10 ng/ml for control, light, moderate and vigorous exercise, respectively. The effect of moderate exercise vs. control on plasma-F was 7 (-6 to 19) ng/ml. Mean baseline-adjusted UFE was 59, 58, 45 and 48 µg/h for control, light, moderate and vigorous exercise, respectively. Moderate exercise resulted in a lower mean baseline-adjusted UFE in comparison with control (mean difference -14; -2 to -25 µg/h). Conclusion: Exercise appears to have no substantial effect on fluoride absorption; however, moderate exercise may reduce fluoride excretion and consequently increase fluoride retention in the body. A larger definitive trial is needed to confirm these findings.",
author = "Alison Innerd",
year = "2014",
language = "English",
note = "International Association for Dental Research Congress 2014 ; Conference date: 10-09-2014 Through 14-09-2014",
url = "https://www.iadr.org/IADR/Meetings/Past-Meetings",

}

Innerd, A 2014, 'Effect of Exercise on Fluoride Metabolism in Adult Humans' International Association for Dental Research Congress 2014, Croatia, 10/09/14 - 14/09/14, .

Effect of Exercise on Fluoride Metabolism in Adult Humans. / Innerd, Alison.

2014. Abstract from International Association for Dental Research Congress 2014, Croatia.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Effect of Exercise on Fluoride Metabolism in Adult Humans

AU - Innerd, Alison

PY - 2014

Y1 - 2014

N2 - The effect of exercise on fluoride metabolism in humans is unknown. This pilot study aimed to investigate the effect of exercise on fluoride ingestion and excretion in adults Objective: To measure urinary fluoride excretion (UFE) and plasma fluoride concentration (plasma-F) following no exercise (control) and three exercise conditions. Methods: In a 4-treatment, 4-period cross-over pilot-trial, 9 healthy volunteers aged 20-35y living in a non-fluoridated area underwent a 2-week “wash-out” with non-fluoridated toothpaste. Prior to each of four different acute conditions separated by one week, with order assigned using a Latin square, participants were given a 1-mg fluoride tablet. The exercise was performed on a stationary bike with the intensity determined by the category-ratio rating scale of perceived exertion (RPE): none (control), light (RPE–3), moderate (RPE–5) and vigorous (RPE-7). Blood and urine samples were taken before (baseline) and after exercise and changes in UFE and plasma-F were measured. Data were analysed using a linear mixed model, adjusting for baseline (pre-exercise) value and any period effect. The mean (95% CI) difference in UFE and plasma-F after each exercise regime was determined. Results: Mean (SD) age of the participants was 25.3 (3.5) y. Mean baseline-adjusted plasma-F was 8, 10, 15 and 10 ng/ml for control, light, moderate and vigorous exercise, respectively. The effect of moderate exercise vs. control on plasma-F was 7 (-6 to 19) ng/ml. Mean baseline-adjusted UFE was 59, 58, 45 and 48 µg/h for control, light, moderate and vigorous exercise, respectively. Moderate exercise resulted in a lower mean baseline-adjusted UFE in comparison with control (mean difference -14; -2 to -25 µg/h). Conclusion: Exercise appears to have no substantial effect on fluoride absorption; however, moderate exercise may reduce fluoride excretion and consequently increase fluoride retention in the body. A larger definitive trial is needed to confirm these findings.

AB - The effect of exercise on fluoride metabolism in humans is unknown. This pilot study aimed to investigate the effect of exercise on fluoride ingestion and excretion in adults Objective: To measure urinary fluoride excretion (UFE) and plasma fluoride concentration (plasma-F) following no exercise (control) and three exercise conditions. Methods: In a 4-treatment, 4-period cross-over pilot-trial, 9 healthy volunteers aged 20-35y living in a non-fluoridated area underwent a 2-week “wash-out” with non-fluoridated toothpaste. Prior to each of four different acute conditions separated by one week, with order assigned using a Latin square, participants were given a 1-mg fluoride tablet. The exercise was performed on a stationary bike with the intensity determined by the category-ratio rating scale of perceived exertion (RPE): none (control), light (RPE–3), moderate (RPE–5) and vigorous (RPE-7). Blood and urine samples were taken before (baseline) and after exercise and changes in UFE and plasma-F were measured. Data were analysed using a linear mixed model, adjusting for baseline (pre-exercise) value and any period effect. The mean (95% CI) difference in UFE and plasma-F after each exercise regime was determined. Results: Mean (SD) age of the participants was 25.3 (3.5) y. Mean baseline-adjusted plasma-F was 8, 10, 15 and 10 ng/ml for control, light, moderate and vigorous exercise, respectively. The effect of moderate exercise vs. control on plasma-F was 7 (-6 to 19) ng/ml. Mean baseline-adjusted UFE was 59, 58, 45 and 48 µg/h for control, light, moderate and vigorous exercise, respectively. Moderate exercise resulted in a lower mean baseline-adjusted UFE in comparison with control (mean difference -14; -2 to -25 µg/h). Conclusion: Exercise appears to have no substantial effect on fluoride absorption; however, moderate exercise may reduce fluoride excretion and consequently increase fluoride retention in the body. A larger definitive trial is needed to confirm these findings.

M3 - Abstract

ER -

Innerd A. Effect of Exercise on Fluoride Metabolism in Adult Humans. 2014. Abstract from International Association for Dental Research Congress 2014, Croatia.