Effect of Exercise on Fluoride Metabolism in Adult Humans

    Research output: Contribution to conferenceAbstract

    Abstract

    The effect of exercise on fluoride metabolism in humans is unknown. This pilot study aimed to investigate the effect of exercise on fluoride ingestion and excretion in adults
    Objective: To measure urinary fluoride excretion (UFE) and plasma fluoride concentration (plasma-F) following no exercise (control) and three exercise conditions.
    Methods: In a 4-treatment, 4-period cross-over pilot-trial, 9 healthy volunteers aged 20-35y living in a non-fluoridated area underwent a 2-week “wash-out” with non-fluoridated toothpaste. Prior to each of four different acute conditions separated by one week, with order assigned using a Latin square, participants were given a 1-mg fluoride tablet. The exercise was performed on a stationary bike with the intensity determined by the category-ratio rating scale of perceived exertion (RPE): none (control), light (RPE–3), moderate (RPE–5) and vigorous (RPE-7). Blood and urine samples were taken before (baseline) and after exercise and changes in UFE and plasma-F were measured. Data were analysed using a linear mixed model, adjusting for baseline (pre-exercise) value and any period effect. The mean (95% CI) difference in UFE and plasma-F after each exercise regime was determined.
    Results: Mean (SD) age of the participants was 25.3 (3.5) y. Mean baseline-adjusted plasma-F was 8, 10, 15 and 10 ng/ml for control, light, moderate and vigorous exercise, respectively. The effect of moderate exercise vs. control on plasma-F was 7 (-6 to 19) ng/ml. Mean baseline-adjusted UFE was 59, 58, 45 and 48 µg/h for control, light, moderate and vigorous exercise, respectively. Moderate exercise resulted in a lower mean baseline-adjusted UFE in comparison with control (mean difference -14; -2 to -25 µg/h).
    Conclusion: Exercise appears to have no substantial effect on fluoride absorption; however, moderate exercise may reduce fluoride excretion and consequently increase fluoride retention in the body. A larger definitive trial is needed to confirm these findings.
    Original languageEnglish
    Publication statusPublished - 2014
    EventInternational Association for Dental Research Congress 2014 - Dubrovnik, Croatia
    Duration: 10 Sep 201414 Sep 2014
    https://www.iadr.org/IADR/Meetings/Past-Meetings

    Conference

    ConferenceInternational Association for Dental Research Congress 2014
    CountryCroatia
    Period10/09/1414/09/14
    Internet address

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    Innerd, A. (2014). Effect of Exercise on Fluoride Metabolism in Adult Humans. Abstract from International Association for Dental Research Congress 2014, Croatia.