Abstract
An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and
avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be
affected by physiological responses to acute exercise. This pilot study investigated the effect of
exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance
following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg
Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baselineadjusted
i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0) ng/ml; ii)
rate of urinary fluoride excretion over 0-8h was 46(15), 44(22), 34(17) and 36(17) μg/h; and iii) rate
of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9) ml/min. The
observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance
with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides
the first data on the effect of exercise with different intensities on fluoride metabolism in humans,
informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the
variability of the effect.
| Original language | English |
|---|---|
| Pages (from-to) | - |
| Journal | Scientific Reports |
| DOIs | |
| Publication status | Published - 19 Nov 2015 |