Abstract
The effect of ibuprofen on cream structure was
studied using two non-ionic cream formulations: low (A)
and high (B) initial viscosity. The saturated concentration
of ibuprofen in each formula was established and drug
loaded creams were prepared over unsaturated and
saturated concentrations. Rheological measurements of
formula A showed a concentration-dependent decrease (p
< 0.05) in cream viscosity and strength that plateaued at
supersaturated concentrations. Formula B was resilient (p
> 0.05) following ibuprofen addition.
studied using two non-ionic cream formulations: low (A)
and high (B) initial viscosity. The saturated concentration
of ibuprofen in each formula was established and drug
loaded creams were prepared over unsaturated and
saturated concentrations. Rheological measurements of
formula A showed a concentration-dependent decrease (p
< 0.05) in cream viscosity and strength that plateaued at
supersaturated concentrations. Formula B was resilient (p
> 0.05) following ibuprofen addition.
| Original language | English |
|---|---|
| Pages (from-to) | 1424-1425 |
| Number of pages | 2 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 62 |
| Issue number | 10 |
| Publication status | Published - 3 Sept 2010 |
| Externally published | Yes |