Effects of Flow Rate Modifications on Reported Analgesia and Quality of Life in Chronic Pain Patients Treated with Continuous Intrathecal Drug Therapy

Christophe Perruchoud, Sam Eldabe, Anne Durrer, Michèle Bovy, Morag Brookes, Grace Madzinga, Fay Garner, Alan M. Batterham, Carole Menoud, Myriam Jacobs, Ash Gulve, Eric Buchser

Research output: Contribution to journalArticle

Abstract

Objective. We compared the analgesia and the quality of life of a constant daily dose of intrathecal drug administered at different flow rates in patients treated for chronic pain. We postulate that the quality of the analgesia, at the same daily dose, will show an infusion rate dependent pattern with decreased pain at higher flow rates.

Patients. Twenty consecutive patients on stable intrathecal treatment were included in a double-blind three-period crossover study where the same daily dose was administered at single, double, and quadruple flow rates in a randomized sequence.

Outcomes Measures. The mean daily pain score and the quality of life (EuroQol measure of health outcome [EQ-5D]) were measured following each flow rate change, after 1 week of stabilization.

Results. Visual analog scale (VAS) scores remained unchanged with all flow rates. Compared with the lowest flow rate, the EQ-5D index decreased with double and even more with quadruple flow rate, suggesting a clinically relevant worsening of the health state with higher flow rates. Adverse events were equally distributed in all groups.

Conclusion. Pain VAS did not significantly change with flow rate. This is consistent with preclinical data showing very limited increase in drug distribution in the cerebrospinal fluid with much larger flow rate augmentation. However, the quality of life decreased consistently as the flow rate increased. This was entirely due to a worsening of the pain and anxiety dimension of the EQ-5D questionnaire, caused presumably by a slight increase in pain rather than adverse events. We suggest that at higher flow rates increased drug dilution results in a decreased effect at the receptor site.
Original languageEnglish
Pages (from-to)571-576
JournalPain Medicine
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2011

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    Perruchoud, C., Eldabe, S., Durrer, A., Bovy, M., Brookes, M., Madzinga, G., Garner, F., Batterham, A. M., Menoud, C., Jacobs, M., Gulve, A., & Buchser, E. (2011). Effects of Flow Rate Modifications on Reported Analgesia and Quality of Life in Chronic Pain Patients Treated with Continuous Intrathecal Drug Therapy. Pain Medicine, 12(4), 571-576. https://doi.org/10.1111/j.1526-4637.2011.01088.x