Effects of melatonin on the thermoregulatory responses to intermittent exercise

Greg Atkinson, Anna Holder, Caroline Robertson, Nicholas Gant, Barry Drust, Thomas Reilly, Jim Waterhouse

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

We examined the effects of a single 2.5-mg dose of melatonin on the thermoregulatory and circulatory responses to intermittent exercise at a room temperature of 27.2 ± 0.4°C (mean ± S.D.), a relative humidity of 55 ± 3% (mean ± S.D.), and a light intensity of 200-300 lux. In a double-blind cross-over study, six male participants ingested either melatonin or placebo at 11:45 hr. Participants then rested in a semi-supine position for 75 min and completed an intermittent running protocol for 66 min at alternating intensities of 40, 60 and 80% of maximal oxygen uptake. Rectal and mean skin temperature, heart rate, blood pressure, skin blood flow, subjective alertness and sleepiness, ratings of perceived exertion (RPE) and thermal strain were recorded. No effects of melatonin were found on these variables measured during the resting period (P > 0.10). During exercise, melatonin was found to moderate the increase in rectal temperature by approximately 0.25°C (P = 0.050) and magnify the increase in skin blood flow (P = 0.047). Postexercise systolic blood pressure was 7.8 ± 2.5 mmHg (mean ± S.D.) lower than before the exercise in the melatonin trial; a change which differed significantly to that in the placebo trial (P = 0.018). Melatonin did not influence subjective alertness and sleepiness before or after exercise and did not change the responses of mean skin temperature, RPE and thermal strain during the exercise (P > 0.10). In summary it is apparent that a 2.5-mg dose of melatonin has hypothermic, but not soporific, effects during 66 min of intermittent exercise performed under moderate heat stress. Whether such effects improve endurance athletic performance in hot conditions remains to be confirmed. Our data also suggest that postexercise systolic hypotension is more marked after ingestion of melatonin.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalJournal of Pineal Research
Volume39
Issue number4
DOIs
Publication statusPublished - 1 Nov 2005

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Melatonin
Skin Temperature
Hot Temperature
Blood Pressure
Post-Exercise Hypotension
Placebos
Athletic Performance
Skin
Temperature
Supine Position
Humidity
Running
Cross-Over Studies
Eating
Heart Rate
Oxygen
Light

Cite this

Atkinson, Greg ; Holder, Anna ; Robertson, Caroline ; Gant, Nicholas ; Drust, Barry ; Reilly, Thomas ; Waterhouse, Jim. / Effects of melatonin on the thermoregulatory responses to intermittent exercise. In: Journal of Pineal Research. 2005 ; Vol. 39, No. 4. pp. 353-359.
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abstract = "We examined the effects of a single 2.5-mg dose of melatonin on the thermoregulatory and circulatory responses to intermittent exercise at a room temperature of 27.2 ± 0.4°C (mean ± S.D.), a relative humidity of 55 ± 3{\%} (mean ± S.D.), and a light intensity of 200-300 lux. In a double-blind cross-over study, six male participants ingested either melatonin or placebo at 11:45 hr. Participants then rested in a semi-supine position for 75 min and completed an intermittent running protocol for 66 min at alternating intensities of 40, 60 and 80{\%} of maximal oxygen uptake. Rectal and mean skin temperature, heart rate, blood pressure, skin blood flow, subjective alertness and sleepiness, ratings of perceived exertion (RPE) and thermal strain were recorded. No effects of melatonin were found on these variables measured during the resting period (P > 0.10). During exercise, melatonin was found to moderate the increase in rectal temperature by approximately 0.25°C (P = 0.050) and magnify the increase in skin blood flow (P = 0.047). Postexercise systolic blood pressure was 7.8 ± 2.5 mmHg (mean ± S.D.) lower than before the exercise in the melatonin trial; a change which differed significantly to that in the placebo trial (P = 0.018). Melatonin did not influence subjective alertness and sleepiness before or after exercise and did not change the responses of mean skin temperature, RPE and thermal strain during the exercise (P > 0.10). In summary it is apparent that a 2.5-mg dose of melatonin has hypothermic, but not soporific, effects during 66 min of intermittent exercise performed under moderate heat stress. Whether such effects improve endurance athletic performance in hot conditions remains to be confirmed. Our data also suggest that postexercise systolic hypotension is more marked after ingestion of melatonin.",
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Atkinson, G, Holder, A, Robertson, C, Gant, N, Drust, B, Reilly, T & Waterhouse, J 2005, 'Effects of melatonin on the thermoregulatory responses to intermittent exercise', Journal of Pineal Research, vol. 39, no. 4, pp. 353-359. https://doi.org/10.1111/j.1600-079X.2005.00256.x

Effects of melatonin on the thermoregulatory responses to intermittent exercise. / Atkinson, Greg; Holder, Anna; Robertson, Caroline; Gant, Nicholas; Drust, Barry; Reilly, Thomas; Waterhouse, Jim.

In: Journal of Pineal Research, Vol. 39, No. 4, 01.11.2005, p. 353-359.

Research output: Contribution to journalArticleResearchpeer-review

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