TY - JOUR
T1 - Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival
AU - de Foubert, Georgina
AU - Khundakar, Ahmad
AU - Zetterström, Tyra S.
PY - 2013/10/11
Y1 - 2013/10/11
N2 - In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis.
AB - In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis.
UR - http://europepmc.org/abstract/med/23981663
U2 - 10.1016/j.neulet.2013.08.029
DO - 10.1016/j.neulet.2013.08.029
M3 - Article
C2 - 23981663
AN - SCOPUS:84884362398
SN - 0304-3940
VL - 553
SP - 211
EP - 215
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -