Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival

Georgina de Foubert, Ahmad Khundakar, Tyra S. Zetterström

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis.

    Original languageEnglish
    Pages (from-to)211-215
    Number of pages5
    JournalNeuroscience Letters
    Volume553
    DOIs
    Publication statusPublished - 11 Oct 2013

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