Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites

Hong Gao, Ying Zhuo, Elizabeth Ashforth, Lixin Zhang

    Research output: Contribution to journalReview article

    Abstract

    Synthetic biology aims to design and build new biological systems with desirable properties, providing the foundation for the biosynthesis of secondary metabolites. The most prominent representation of synthetic biology has been used in microbial engineering by recombinant DNA technology. However, there are advantages of using a deleted host, and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genome-reduced microbes. This review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites.

    Original languageEnglish
    Pages (from-to)621-6
    Number of pages6
    JournalProtein and Cell
    Volume1
    Issue number7
    DOIs
    Publication statusPublished - Jul 2010

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