Entangled but Finicky Ingression Protein Complexes for Successful Cytokinesis

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    Cytokinesis is the final stage of mitosis that leads to the physical separation of two daughter cells and comprises a sequence of events such as actomyosin ring contraction, ingression and remodeling of the extracellular matrix. All these processes are tightly regulated in space and time through a network of proteins. Defects in cytokinesis may increase the risk of tumor formation. Using a combination of cell biology and molecular techniques, along with biochemical experiments, Foltman et al. [27] have dissected how the “ingression protein complexes” (IPCs) localize and coordinate to ensure proper cytokinesis. Interestingly, a particular glycosyltransferase, named Chs2, is the hub protein that assures a successful cytokinesis in budding yeast.
    Original languageEnglish
    Number of pages6
    Journalpostdoc journal
    Issue number5
    Publication statusPublished - 1 May 2016


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