Estrogen receptor ligands affect mitochondrial activity in SH-SY5Y human neuroblastoma cells.

Peter B Simpson, Anthony J Woollacott, Zahid Moneer, Vikki Rand, Guy R Seabrook

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have studied the pharmacological regulation of mitochondrial activity in a human neuroblastoma cell line. Cyclosporin A was found to directly alter mitochondrial membrane potential and to decrease mitochondrial permeability as measured using calcein. The estrogen receptor ligands tamoxifen, nafoxidine and clomiphene were identified as agents which affect mitochondrial membrane potential in a cyclosporin A-like manner. Also when mitochondrial permeability was measured using calcein, tamoxifen, nafoxidine and clomiphene were effective in inhibiting dye loss from mitochondria. Nafoxidine and cyclosporin A inhibit effects of mastoparan on SH-SY5Y mitochondria. These studies indicate that estrogen receptor ligands appear to affect mitochondria in a cyclosporin A-like manner in human neuroblastoma cells.
    Original languageEnglish
    Pages (from-to)957-960
    Number of pages4
    JournalNeuroReport
    Volume13
    Issue number7
    DOIs
    Publication statusPublished - 24 May 2002

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