TY - JOUR
T1 - Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties
AU - Raveendran, S.
AU - Palaninathan, V.
AU - Nagaoka, Y.
AU - Fukuda, T.
AU - Iwai, S.
AU - Higashi, T.
AU - Mizuki, T.
AU - Sakamoto, Y.
AU - Mohanan, P.V.
AU - Maekawa, T.
AU - Kumar, D.S.
PY - 2015/3/6
Y1 - 2015/3/6
N2 - Polysaccharides that show finest bioactivities and physicochemical properties are always promising for bionanoscience applications. Mauran is such a macromolecule extracted from halophilic bacterium, Halomonas maura for biotechnology and nanoscience applications. Antioxidant properties of MR/CH nanoparticles were studied using biochemical assays to prove the versatility of these test nanoparticles for biomedical applications. Here, we demonstrate the prospects of extremophilic polysaccharide, mauran based nanoparticles for scavenging reactive oxygen species in both in vitro and ex vivo conditions. 5-fluorouracil loaded MR/CH nanoparticles were tested for anticancer proliferation and compared their therapeutic efficiency using breast adenocarcinoma and glioma cells. Fluorescently labeled nanoparticles were employed to show the cellular uptake of these nanocarriers using confocal microscopic imaging and flow cytometry.
AB - Polysaccharides that show finest bioactivities and physicochemical properties are always promising for bionanoscience applications. Mauran is such a macromolecule extracted from halophilic bacterium, Halomonas maura for biotechnology and nanoscience applications. Antioxidant properties of MR/CH nanoparticles were studied using biochemical assays to prove the versatility of these test nanoparticles for biomedical applications. Here, we demonstrate the prospects of extremophilic polysaccharide, mauran based nanoparticles for scavenging reactive oxygen species in both in vitro and ex vivo conditions. 5-fluorouracil loaded MR/CH nanoparticles were tested for anticancer proliferation and compared their therapeutic efficiency using breast adenocarcinoma and glioma cells. Fluorescently labeled nanoparticles were employed to show the cellular uptake of these nanocarriers using confocal microscopic imaging and flow cytometry.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84924935530&partnerID=MN8TOARS
U2 - 10.1016/j.ijbiomac.2015.03.001
DO - 10.1016/j.ijbiomac.2015.03.001
M3 - Article
SN - 0141-8130
VL - 76
SP - 310
EP - 319
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -