First human experiments with a novel non-invasive, non-optical continuous glucose monitoring system

A. Caduff, E. Hirt, Yu Feldman, Z. Ali, L. Heinemann

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

This paper describes a non-invasive continuous glucose monitoring system based on impedance spectroscopy. Changes in the glucose concentrations can be monitored by varying the frequency in the radio band over a range, optimised to measure the impact of glucose on the impedance pattern. A number of clinical-experimental studies (hyperglycaemic excursions) were performed with healthy subjects in order to prove the applicability of this approach. The sensor used in these experiments is the size of a wristwatch and holds an open resonant circuit coupled to the skin and a circuit, performing an impedance measurement. In most cases, the experiments showed a good correlation between changes in blood glucose and the sensor recordings. A detailed description of the trials is presented. The results of this first series of experiments can be considered as a proof of concept for this novel non-invasive monitoring approach. Nevertheless, partly due to the indirect measurement, a considerable number of questions remain to be clarified.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalBiosensors and Bioelectronics
Volume19
Issue number3
DOIs
Publication statusPublished - 30 Nov 2003

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