Free-living physical activity as a novel outcome measure in patients with intermittent claudication

C. L. Clarke, R. J. Holdsworth, Cormac Ryan, M. H. Granat

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective: To develop a method of event-based analysis that quantifies the fragmented nature of walking bouts in individuals with intermittent claudication [IC] and compare outcomes with age and gender-matched healthy controls. Design: Cross-sectional. Materials: The activPAL™ physical activity monitor. Methods: 7-day physical activity patterns were compared between individuals with IC (n = 30) and controls matched for age and gender (n = 30). The ratio of the number of walking events to upright events was calculated to provide an event-based claudication index (EBCI) that represented the fragmented nature of walking bouts commonly reported in those with IC. Results: Individuals with IC had a greater EBCI than age matched controls indicating a more fragmented walking pattern (5.8 ± 2.0 vs. 7.7 ± 3.1, p < 0.01). The difference between groups was more pronounced when the EBCI was calculated from upright events that included >400 steps (23.4 ± 11.3 vs. 35.8 ± 14.2, p < 0.01). Conclusion: The classic fragmented stop/start walking pattern universally described by individuals with IC can be quantified using the EBCI. This method of measurement potentially provides a novel method of assessing the effectiveness of clinical interventions for this patient group.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number2
Publication statusPublished - 1 Feb 2013


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