Abstract
Octodon degus (O. degus), a long-lived rodent, provides us with a unique
opportunity to search for molecular pathways that are associated with enhanced
longevity in mammals. This rodent from Chile spontaneously develops an analog of
sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes
wide use of spatial memory to find and hide food. This cognitive ability is thought to be
rooted in what is commonly known as the GPS of the mammalian brain, a collection of
structures centred around the hippocampus and neighbouring cortical areas. A fraction
of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyper-
phosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but
also several other conditions comorbid t o AD like diabetes mellitus type 2, macular and
retinal degeneration and atherosclerosis
opportunity to search for molecular pathways that are associated with enhanced
longevity in mammals. This rodent from Chile spontaneously develops an analog of
sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes
wide use of spatial memory to find and hide food. This cognitive ability is thought to be
rooted in what is commonly known as the GPS of the mammalian brain, a collection of
structures centred around the hippocampus and neighbouring cortical areas. A fraction
of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyper-
phosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but
also several other conditions comorbid t o AD like diabetes mellitus type 2, macular and
retinal degeneration and atherosclerosis
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 7 Dec 2020 |
| Event | Alzheimer's Association International Conference 2020 - Duration: 27 Jul 2020 → 27 Jul 2020 https://alz.confex.com/alz/20amsterdam/meetingapp.cgi |
Conference
| Conference | Alzheimer's Association International Conference 2020 |
|---|---|
| Period | 27/07/20 → 27/07/20 |
| Internet address |