From genes to cognition: Octodon degus, an animal model for AD translational research

Matias Mugnaini, Robert Deacon, Guido Zampieri, Peter Vanderklish, Claudio Angione, Emilio Kropff, Patricia Cogram

Research output: Contribution to conferenceAbstractpeer-review


Octodon degus (O. degus), a long-lived rodent, provides us with a unique
opportunity to search for molecular pathways that are associated with enhanced
longevity in mammals. This rodent from Chile spontaneously develops an analog of
sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes
wide use of spatial memory to find and hide food. This cognitive ability is thought to be
rooted in what is commonly known as the GPS of the mammalian brain, a collection of
structures centred around the hippocampus and neighbouring cortical areas. A fraction
of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyper-
phosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but
also several other conditions comorbid t o AD like diabetes mellitus type 2, macular and
retinal degeneration and atherosclerosis
Original languageEnglish
Number of pages1
Publication statusPublished - 7 Dec 2020
EventAlzheimer's Association International Conference 2020 -
Duration: 27 Jul 202027 Jul 2020


ConferenceAlzheimer's Association International Conference 2020
Internet address


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