Gene map of the extended human MHC.

Roger Horton, Laurens Wilming, Vikki Rand, Ruth C Lovering, Elspeth A Bruford, Varsha K Khodiyar, Michael J Lush, Sue Povey, Conover C Talbot, Mathew W Wright, Hester M Wain, John Trowsdale, Andreas Ziegler, Stephan Beck

    Research output: Contribution to journalArticlepeer-review


    The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.
    Original languageEnglish
    Pages (from-to)889-899
    Number of pages11
    JournalNature Reviews Genetics
    Publication statusPublished - 1 Dec 2004


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