Gene map of the extended human MHC.

Roger Horton; Laurens Wilming; Vikki Rand; Ruth C Lovering; Elspeth A Bruford; Varsha K Khodiyar; Michael J Lush; Sue Povey; Conover C Talbot; Mathew W Wright; Hester M Wain; John Trowsdale; Andreas Ziegler; Stephan Beck

doi:10.1038/nrg1489

Gene map of the extended human MHC.

Roger Horton, Laurens Wilming, Vikki Rand, Ruth C Lovering, Elspeth A Bruford, Varsha K Khodiyar, Michael J Lush, Sue Povey, Conover C Talbot, Mathew W Wright, Hester M Wain, John Trowsdale, Andreas Ziegler, Stephan Beck

Research output: Contribution to journal › Article › peer-review

Abstract

The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

Original language	English
Pages (from-to)	889-899
Number of pages	11
Journal	Nature Reviews Genetics
Volume	5
DOIs	https://doi.org/10.1038/nrg1489
Publication status	Published - 1 Dec 2004

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title = "Gene map of the extended human MHC.",

abstract = "The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.",

author = "Roger Horton and Laurens Wilming and Vikki Rand and Lovering, {Ruth C} and Bruford, {Elspeth A} and Khodiyar, {Varsha K} and Lush, {Michael J} and Sue Povey and Talbot, {Conover C} and Wright, {Mathew W} and Wain, {Hester M} and John Trowsdale and Andreas Ziegler and Stephan Beck",

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doi = "10.1038/nrg1489",

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AU - Horton, Roger

AU - Wilming, Laurens

AU - Rand, Vikki

AU - Lovering, Ruth C

AU - Bruford, Elspeth A

AU - Khodiyar, Varsha K

AU - Lush, Michael J

AU - Povey, Sue

AU - Talbot, Conover C

AU - Wright, Mathew W

AU - Wain, Hester M

AU - Trowsdale, John

AU - Ziegler, Andreas

AU - Beck, Stephan

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

AB - The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

UR - http://europepmc.org/abstract/med/15573121

U2 - 10.1038/nrg1489

DO - 10.1038/nrg1489

M3 - Article

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SN - 1471-0056

VL - 5

SP - 889

EP - 899

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

ER -

Gene map of the extended human MHC.

Abstract

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