Helicobacter pylori is the most predominant bacterium in almost 50% of the world's population and colonization causes a persistent inflammatory response leading to chronic gastritis. It shows high genetic diversity and individuals generally harbour a distinct bacterial population. With the advancement of whole-genome sequencing technology, new H. pylori subpopulations have been identified that show admixture between various H. pylori strains. Genotypic variation of H. pylori may be related to the presence of virulence factors among strains and is associated with different outcomes of infection in different individuals. This review summarizes the genetic diversity in H. pylori strain populations and its virulence characteristics responsible for variable outcomes in different ethnic groups.
|Journal||Infection, Genetics and Evolution|
|Early online date||16 Dec 2019|
|Publication status||Published - 18 Dec 2019|
Bibliographical noteFunding Information:
This work is partly funded by fundamental research grant from Ministry of Higher Education of Malaysia with a grant no. FRGS/2/2014/SKK04/UKM/02/01.
This work is partly funded by fundamental research grant from Ministry of Higher Education of Malaysia with a grant no. FRGS/2/2014/SKK04/UKM/02/01 .
© 2019 Elsevier B.V.