Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

Mostafa Kamal Masud; Md Nazmul Islam; Md Hakimul Haque; Shunsuke Tanaka; Vinod Gopalan; Gursel Alici; Nam-Trung Nguyen; Alfred K. Lam; Md Shahriar A. Hossain; Yusuke Yamauchi; Muhammad J. A. Shiddiky

doi:10.1039/C7CC04789D

Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

Mostafa Kamal Masud, Md Nazmul Islam, Md Hakimul Haque, Shunsuke Tanaka, Vinod Gopalan, Gursel Alici, Nam-Trung Nguyen, Alfred K. Lam, Md Shahriar A. Hossain, Yusuke Yamauchi, Muhammad J. A. Shiddiky

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Abstract

This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

Original language	English
Pages (from-to)	8231-8234
Number of pages	3
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/C7CC04789D
Publication status	Published - 30 Jul 2017

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@article{b243307483644e20b65b374155ce4c1f,

title = "Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA",

abstract = "This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).",

author = "{Kamal Masud}, Mostafa and Islam, {Md Nazmul} and Haque, {Md Hakimul} and Shunsuke Tanaka and Vinod Gopalan and Gursel Alici and Nam-Trung Nguyen and Lam, {Alfred K.} and Hossain, {Md Shahriar A.} and Yusuke Yamauchi and Shiddiky, {Muhammad J. A.}",

year = "2017",

month = jul,

day = "30",

doi = "10.1039/C7CC04789D",

language = "English",

pages = "8231--8234",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

AU - Kamal Masud, Mostafa

AU - Islam, Md Nazmul

AU - Haque, Md Hakimul

AU - Tanaka, Shunsuke

AU - Gopalan, Vinod

AU - Alici, Gursel

AU - Nguyen, Nam-Trung

AU - Lam, Alfred K.

AU - Hossain, Md Shahriar A.

AU - Yamauchi, Yusuke

AU - Shiddiky, Muhammad J. A.

PY - 2017/7/30

Y1 - 2017/7/30

N2 - This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

AB - This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

UR - http://dx.doi.org/10.1039/C7CC04789D

U2 - 10.1039/C7CC04789D

DO - 10.1039/C7CC04789D

M3 - Article

SN - 1359-7345

SP - 8231

EP - 8234

JO - Chemical Communications

JF - Chemical Communications

ER -

Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

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