This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).
Kamal Masud, M., Islam, M. N., Haque, M. H., Tanaka, S., Gopalan, V., Alici, G., Nguyen, N-T., Lam, A. K., Hossain, M. S. A., Yamauchi, Y., & Shiddiky, M. J. A. (2017). Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA. Chemical Communications, 8231-8234. https://doi.org/10.1039/C7CC04789D