Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

Mostafa Kamal Masud, Md Nazmul Islam, Md Hakimul Haque, Shunsuke Tanaka, Vinod Gopalan, Gursel Alici, Nam-Trung Nguyen, Alfred K. Lam, Md Shahriar A. Hossain, Yusuke Yamauchi, Muhammad J. A. Shiddiky

    Research output: Contribution to journalArticlepeer-review

    Abstract

    This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).
    Original languageEnglish
    Pages (from-to)8231-8234
    Number of pages3
    JournalChemical Communications
    DOIs
    Publication statusPublished - 30 Jul 2017

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