Selective detection of dopamine is still a challenge due to the strong interference from ascorbic acid (AA). A hybrid dopamine electrochemical sensor was fabricated by boron-doped diamond (BDD) film co-modified with gold nanoparticles and graphite-coated nickel nanoparticles (Au-C@Ni/BDD). Highly sensitive and selective detection toward dopamine was achieved by multiple electrochemical anodic polarization treatment (EAPT) with relatively mild voltage (+ 1.6 V vs. Ag/AgCl) on Au-C@Ni/BDD electrode. Specifically, the oxidation peak separation between ascorbic acid and dopamine reached 166 mV, and the limit of detection of dopamine was as low as 0.015 μM in a linear concentration range of 0.05–100 μM with the sensitivity up to 1.99 μA μM −1 cm −2 even in the presence of interference of high-level AA. These could be ascribed to the electrocatalytically active sites and functional oxygen-containing groups of the hybrid electrodes produced by the EAPT and the excellent catalytical activity of gold nanoparticles. Graphical Abstract: [Figure not available: see fulltext.].
Bibliographical noteFunding Information:
We gratefully acknowledge the National Key Research and Development Program of China (No. 2016YFB0301402, No. 2016YFB0402705), the National Natural Science Foundation of China (No. 51601226, No. 51874370, No. 51302173), the State Key Laboratory of Powder Metallurgy, the Fundamental Research Funds for the Central Universities of Central South University (2018zzts014 and 2017gczd024), and the financial supports from the Postgraduate Research and Innovation Project of Central South University (No. 1053320170851, No. 2018zzts403), China. The authors also wish to thank the reviewers and editor for kindly giving revising suggestions.
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