Abstract
The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D hydrogel structures can be modified by integrating with nanostructures. Such modifications can enhance their responsiveness to mechanical, optical, thermal, magnetic, and electric stimuli, which in turn can enhance the practicality of biosensors in clinical settings. This review describes the synthesis and kinetics of gel networks and exploitation of nanostructure-integrated hydrogels in biosensing. With an emphasis on different integration strategies of hydrogel with nanostructures, this review highlights the importance of hydrogel nanostructures as one of the most favorable candidates for developing ultrasensitive biosensors. Moreover, hydrogel nanoarchitectonics are also portrayed as a promising candidate for fabricating next-generation robust biosensors.
Original language | English |
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Article number | 2107571 |
Pages (from-to) | e2107571 |
Journal | Small |
Volume | 18 |
Issue number | 26 |
DOIs | |
Publication status | Published - 27 May 2022 |
Bibliographical note
Funding Information:This study is supported by the JSPS fellowship to M.K.M (Grant Number P20039). Y.V.K. acknowledges the financial support from Advance Queensland (AQIRF043‐2020RD3). Y.Y. thanks the financial support from ARC Discovery Project (ARC DP190102944) and JST‐ERATO Yamauchi Materials Space‐Tectonics Project (JPMJER2003). The authors are also grateful to the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano‐ and micro‐fabrication facilities for Australian researchers.
Funding Information:
This study is supported by the JSPS fellowship to M.K.M (Grant Number P20039). Y.V.K. acknowledges the financial support from Advance Queensland (AQIRF043-2020RD3). Y.Y. thanks the financial support from ARC Discovery Project (ARC DP190102944) and JST-ERATO Yamauchi Materials Space-Tectonics Project (JPMJER2003). The authors are also grateful to the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano- and micro-fabrication facilities for Australian researchers.
Publisher Copyright:
© 2022 Wiley-VCH GmbH.