Improved control strategies for the environment within cell culture bioreactors

Jonathan Jones, Didier Kindembe, Harvey Branton, Najib Lawal, Eduardo Lopez Martinez, John Mack, Shuo Shi, Ron Patton, Gary Montague

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This paper describes the development of improved control strategies for the standard environmental conditions in a fed-batch bioreactor used for monoclonal antibody cell culture. The consequences of relying on fixed parameter PID based controllers are considered and poor performance is demonstrated as a consequence of non-linearity and loop interactions. The benefits from adopting a more sophisticated control strategy are considered. Model Predictive Control (MPC) relies on a process model that can be identified from small system perturbations. It considers the predicted longer-term response and consequently can deliver improved control and satisfy user defined constraints. Results from experimental trials demonstrate the capability of MPC and the merits are discussed with regards to industrial application.
Original languageEnglish
JournalFood and Bioproducts Processing
Early online date16 Feb 2023
Publication statusE-pub ahead of print - 16 Feb 2023


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