In silico RNA Interference: A Powerful Weapon against Virus Defense in Plants

Shweta Kuba, Jawaid Ahmad Khan

Research output: Chapter in Book/Report/Conference proceedingChapter


Virus diseases are major threat for agricultural production. They cause severe damages to crops leading to huge economic losses. Upon virus infection, plant defence system triggers RNA interference (RNAi) pathway which is a homologydependent gene silencing mechanism implicating degradation of complementary RNA. Employing small RNA molecules such as miRNA and siRNA, RNAi has been widely manipulated to engineer resistance in plants against viruses. Small RNA species have been demonstrated to play primary roles in several regulatory pathways inside the host. To counteract host-mediated RNA silencing, viruses have evolved several silencing suppressor genes. A large number of experimental evidences validate that inhibition of cytoplasmic RNA silencing occurs via virus derived suppressor genes. In this review, several conventional and nonconventional control measures to combat virus diseases have been described. Progression of In silico biology, involving miRNA and siRNA, equip the plant with one more arm in repertoire of tools against viruses. It holds great promise in delivering immunity against virus infection. Future investigations will provide more information about small RNA(s) expression profiles in response to virus
Original languageUndefined
Title of host publicationBiotechnology
Subtitle of host publicationProgress and Applications
EditorsSaif Hameed, Zeeshan Fatima
PublisherDaya Publishing House
ISBN (Print)978-93-5124-729-6
Publication statusPublished - 1 Jan 2016

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