Influence of acute plasma volume expansion on V̇O 2 kinetics, V̇O 2 peak, and performance during high-intensity cycle exercise

Nicolas Berger, Iain T. Campbell, Daryl P. Wilkerson, Andrew M. Jones

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Abstract

The purpose of this study was to examine the influence of acute plasma volume expansion (APVE) on oxygen uptake (V̇O 2) kinetics, V̇O 2 peak, and time to exhaustion during severe-intensity exercise. Eight recreationally active men performed "step" cycle ergometer exercise tests at a work rate requiring 70% of the difference between the gas-exchange threshold and V̇O 2 max on three occasions: twice as a "control" (Con) and once after intravenous infusion of a plasma volume expander (Gelofusine; 7 ml/kg body mass). Pulmonary gas exchange was measured breath by breath. APVE resulted in a significant reduction in hemoglobin concentration (preinfusion: 16.0 ± 1.0 vs. postinfusion: 14.7 ± 0.8 g/dl; P < 0.001) and hematocrit (preinfusion: 44 ± 2 vs. postinfusion: 41 ± 3%; P < 0.01). Despite this reduction in arterial O 2 content, APVE had no effect on V̇O 2 kinetics (phase II time constant, Con: 33 ± 15 vs. APVE: 34 ± 12 s; P = 0.74), and actually resulted in an increased V̇O 2 peak (Con: 3.90 ± 0.56 vs. APVE: 4.12 ± 0.55 l/min; P = 0.006) and time to exhaustion (Con: 365 ± 58 vs. APVE: 424 ± 64 s; P = 0.04). The maximum O 2 pulse was also enhanced by the treatment (Con: 21.3 ± 3.4 vs. APVE: 22.7 ± 3.4 ml/beat; P = 0.04). In conclusion, APVE does not alter V̇O 2 kinetics but enhances V̇O 2 peak and exercise tolerance during high-intensity cycle exercise in young recreationally active subjects.

Original languageEnglish
Pages (from-to)707-714
Number of pages8
JournalJournal of Applied Physiology
Volume101
Issue number3
DOIs
Publication statusPublished - 14 Sep 2006

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Plasma Volume
Exercise
Polygeline
Plasma Substitutes
Pulmonary Gas Exchange
Exercise Tolerance
Exercise Test
Hematocrit
Intravenous Infusions
Pulse
Hemoglobins
Gases
Oxygen

Cite this

@article{52a4b926c18f4fd88d25efb422076e15,
title = "Influence of acute plasma volume expansion on V̇O 2 kinetics, V̇O 2 peak, and performance during high-intensity cycle exercise",
abstract = "The purpose of this study was to examine the influence of acute plasma volume expansion (APVE) on oxygen uptake (V̇O 2) kinetics, V̇O 2 peak, and time to exhaustion during severe-intensity exercise. Eight recreationally active men performed {"}step{"} cycle ergometer exercise tests at a work rate requiring 70{\%} of the difference between the gas-exchange threshold and V̇O 2 max on three occasions: twice as a {"}control{"} (Con) and once after intravenous infusion of a plasma volume expander (Gelofusine; 7 ml/kg body mass). Pulmonary gas exchange was measured breath by breath. APVE resulted in a significant reduction in hemoglobin concentration (preinfusion: 16.0 ± 1.0 vs. postinfusion: 14.7 ± 0.8 g/dl; P < 0.001) and hematocrit (preinfusion: 44 ± 2 vs. postinfusion: 41 ± 3{\%}; P < 0.01). Despite this reduction in arterial O 2 content, APVE had no effect on V̇O 2 kinetics (phase II time constant, Con: 33 ± 15 vs. APVE: 34 ± 12 s; P = 0.74), and actually resulted in an increased V̇O 2 peak (Con: 3.90 ± 0.56 vs. APVE: 4.12 ± 0.55 l/min; P = 0.006) and time to exhaustion (Con: 365 ± 58 vs. APVE: 424 ± 64 s; P = 0.04). The maximum O 2 pulse was also enhanced by the treatment (Con: 21.3 ± 3.4 vs. APVE: 22.7 ± 3.4 ml/beat; P = 0.04). In conclusion, APVE does not alter V̇O 2 kinetics but enhances V̇O 2 peak and exercise tolerance during high-intensity cycle exercise in young recreationally active subjects.",
author = "Nicolas Berger and Campbell, {Iain T.} and Wilkerson, {Daryl P.} and Jones, {Andrew M.}",
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Influence of acute plasma volume expansion on V̇O 2 kinetics, V̇O 2 peak, and performance during high-intensity cycle exercise. / Berger, Nicolas ; Campbell, Iain T.; Wilkerson, Daryl P.; Jones, Andrew M.

In: Journal of Applied Physiology, Vol. 101, No. 3, 14.09.2006, p. 707-714.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Influence of acute plasma volume expansion on V̇O 2 kinetics, V̇O 2 peak, and performance during high-intensity cycle exercise

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N2 - The purpose of this study was to examine the influence of acute plasma volume expansion (APVE) on oxygen uptake (V̇O 2) kinetics, V̇O 2 peak, and time to exhaustion during severe-intensity exercise. Eight recreationally active men performed "step" cycle ergometer exercise tests at a work rate requiring 70% of the difference between the gas-exchange threshold and V̇O 2 max on three occasions: twice as a "control" (Con) and once after intravenous infusion of a plasma volume expander (Gelofusine; 7 ml/kg body mass). Pulmonary gas exchange was measured breath by breath. APVE resulted in a significant reduction in hemoglobin concentration (preinfusion: 16.0 ± 1.0 vs. postinfusion: 14.7 ± 0.8 g/dl; P < 0.001) and hematocrit (preinfusion: 44 ± 2 vs. postinfusion: 41 ± 3%; P < 0.01). Despite this reduction in arterial O 2 content, APVE had no effect on V̇O 2 kinetics (phase II time constant, Con: 33 ± 15 vs. APVE: 34 ± 12 s; P = 0.74), and actually resulted in an increased V̇O 2 peak (Con: 3.90 ± 0.56 vs. APVE: 4.12 ± 0.55 l/min; P = 0.006) and time to exhaustion (Con: 365 ± 58 vs. APVE: 424 ± 64 s; P = 0.04). The maximum O 2 pulse was also enhanced by the treatment (Con: 21.3 ± 3.4 vs. APVE: 22.7 ± 3.4 ml/beat; P = 0.04). In conclusion, APVE does not alter V̇O 2 kinetics but enhances V̇O 2 peak and exercise tolerance during high-intensity cycle exercise in young recreationally active subjects.

AB - The purpose of this study was to examine the influence of acute plasma volume expansion (APVE) on oxygen uptake (V̇O 2) kinetics, V̇O 2 peak, and time to exhaustion during severe-intensity exercise. Eight recreationally active men performed "step" cycle ergometer exercise tests at a work rate requiring 70% of the difference between the gas-exchange threshold and V̇O 2 max on three occasions: twice as a "control" (Con) and once after intravenous infusion of a plasma volume expander (Gelofusine; 7 ml/kg body mass). Pulmonary gas exchange was measured breath by breath. APVE resulted in a significant reduction in hemoglobin concentration (preinfusion: 16.0 ± 1.0 vs. postinfusion: 14.7 ± 0.8 g/dl; P < 0.001) and hematocrit (preinfusion: 44 ± 2 vs. postinfusion: 41 ± 3%; P < 0.01). Despite this reduction in arterial O 2 content, APVE had no effect on V̇O 2 kinetics (phase II time constant, Con: 33 ± 15 vs. APVE: 34 ± 12 s; P = 0.74), and actually resulted in an increased V̇O 2 peak (Con: 3.90 ± 0.56 vs. APVE: 4.12 ± 0.55 l/min; P = 0.006) and time to exhaustion (Con: 365 ± 58 vs. APVE: 424 ± 64 s; P = 0.04). The maximum O 2 pulse was also enhanced by the treatment (Con: 21.3 ± 3.4 vs. APVE: 22.7 ± 3.4 ml/beat; P = 0.04). In conclusion, APVE does not alter V̇O 2 kinetics but enhances V̇O 2 peak and exercise tolerance during high-intensity cycle exercise in young recreationally active subjects.

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