Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages.

Keyphrases

• Heat Shock Protein 90 (Hsp90) 100%
• Developmental Stages 100%
• Leishmania Mexicana 100%
• Global Phosphoproteome 100%
• Amastigote 64%
• Leishmania 57%
• Promastigote 35%
• Phosphorylation 28%
• RNA-binding Protein 28%
• Phosphoproteomics 28%
• Life Cycle Stages 21%
• Mass Spectrometry Analysis 14%
• Post-translational Modification 14%
• Protein Phosphorylation 14%
• Phosphoprotein 14%
• Etiological Agents 14%
• Quantitative Proteomics 14%
• Heat Shock Protein 90 Inhibitor 14%
• Tandem Mass Tag Labeling 14%
• Unicellular Parasite 14%
• Cycle Control 14%
• L. Mexicana 7%
• Molecular Mechanism 7%
• Heat Shock 7%
• Opposite Effects 7%
• Infectious Diseases 7%
• Neglected Tropical Diseases 7%
• Leishmaniasis 7%
• Signaling Molecules 7%
• Highly Sensitive 7%
• Molecular Effects 7%
• Low pH 7%
• Higher Eukaryotes 7%
• Heat Effect 7%
• Heat Shock Protein 70 (HSP70) 7%
• Kinase Activity 7%
• Protein Folding 7%
• Microtubule Motors 7%
• Protein Kinase 7%
• Molecular Targets 7%
• Ribosomal Protein 7%
• Extracellular Signaling 7%
• RNA Processing 7%
• RNA Helicase 7%
• Chemical Inhibitors 7%
• Downstream Effects 7%
• Client Proteins 7%
• Tanespimycin 7%
• Large Array 7%
• Motor Activity 7%
• Environmental Triggers 7%
• Evolutionarily Conserved 7%
• Phosphorylated Protein 7%
• Chaperone Proteins 7%
• Cell Cycle Checkpoint 7%
• Dephosphorylation 7%
• Proton Channel 7%
• Robust Identification 7%
• Leishmaniasis Treatment 7%
• RNA Decay 7%
• Channel Activity 7%
• Helicase Domain 7%
• Co-chaperone 7%
• PH Shock 7%

Biochemistry, Genetics and Molecular Biology

• Heat Shock Protein 100%
• Developmental Stage 100%
• Leishmania mexicana 100%
• Amastigote 64%
• Leishmania 57%
• Promastigote 35%
• RNA-binding Protein 28%
• Phosphoprotein 21%
• Life Cycle Stage 21%
• Mass Spectrometry 14%
• Posttranslational Modification 14%
• Protein Phosphorylation 14%
• Tandem Mass Tag 14%
• Quantitative Proteomics 14%
• Heat Shock Protein 90 Inhibitor 14%
• Life Cycle 14%
• Maturation 7%
• Dynamics 7%
• Heat Shock 7%
• Kinase 7%
• Phosphotransferase 7%
• Eukaryote 7%
• Protein Kinases 7%
• Protein Folding 7%
• RNA Processing 7%
• RNA Helicase 7%
• Ribosomal Protein 7%
• Cell Cycle Checkpoint 7%
• Co-Chaperone 7%
• Dephosphorylation 7%
• Signaling Protein 7%
• Chaperone (Protein) 7%
• Motor Activity 7%

Immunology and Microbiology

• Heat Shock 100%
• Leishmania mexicana 100%
• Developmental Stage 100%
• Amastigote 52%
• Leishmania 47%
• Promastigote 29%
• Protein RNA Binding 23%
• Life Cycle Stage 17%
• Protein Processing 11%
• Protein Phosphorylation 11%
• Life Cycle 11%
• Leishmaniasis 11%
• Dynamics 5%
• Maturation 5%
• Infectious Disease 5%
• Eukaryote 5%
• Protein Folding 5%
• Microtubule 5%
• RNA Processing 5%
• Cell Cycle Checkpoint 5%
• Dephosphorylation 5%
• Parasitology 5%