Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease.

Keyphrases

• Reactive Oxygen Species 100%
• Nitric Oxide 100%
• Mitochondrial Dysfunction 100%
• Genomic Approaches 100%
• Major Pathway 100%
• Upstream Regulator 100%
• Late-onset Alzheimer's Disease 100%
• Integrated Genomics 100%
• Macrophages 66%
• Differentially Expressed Genes 66%
• Alzheimer's Disease Brain 66%
• Late-onset AD 66%
• Toll-like Receptor 4 (TLR4) 66%
• Gene Expression 33%
• Pathway Activation 33%
• Path Analysis 33%
• Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) 33%
• Braak Stage 33%
• Cerebral Atrophy 33%
• Protein-protein Interaction Network Analysis 33%
• Mitochondrial Genes 33%
• LPS Signaling 33%
• Healthy Aging Subjects 33%
• Inflammatory Pathways 33%
• Meta-analysis Approach 33%
• Phosphatidylinositol Metabolism 33%
• Upstream Regulator Analysis 33%
• Inflammatory Macrophages 33%
• Activated Pathways 33%
• Rictor 33%
• Calcium Signaling 33%
• DOK3 33%
• Nuclear factor-κB 33%
• NFKBIA 33%
• Mannosylation 33%
• TLR4 Ligand 33%
• TYROBP 33%

Biochemistry, Genetics and Molecular Biology

• Nitric Oxide 100%
• Macrophage 100%
• TLR4 100%
• Genomics 100%
• Mitochondrial Disorder 100%
• Metabolic Pathway 33%
• Gene Expression 33%
• Protein-Protein Interaction 33%
• Mitochondrial Gene 33%
• Healthy Aging 33%
• RICTOR 33%
• STAT3 33%
• TREM2 33%
• Calcium Signaling 33%
• Phosphatidylinositol 33%

Neuroscience

• Nitric Oxide 100%
• Alzheimer's Disease 100%
• Macrophage 100%
• Reactive Oxygen Species 100%
• TLR 4 100%
• Meta-Analysis 33%
• Gene Expression 33%
• Metabolic Pathway 33%
• Protein-Protein Interaction 33%
• STAT3 33%
• Phosphatidylinositol 33%
• Mitochondrial Gene 33%
• Calcium Signaling 33%