TY - JOUR
T1 - Interindividual responses of appetite to acute exercise: a replicated crossover study
AU - Goltz, Fernanda
AU - Thackray, Alice
AU - King, James
AU - Dorling, James
AU - Atkinson, Gregory
AU - Stensel, David John
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Purpose: Acute exercise transiently suppresses appetite, which coincides with alterations in
appetite-regulatory hormone concentrations. Individual variability in these responses is
suspected, but replicated trials are needed to quantify them robustly. We examined the reproducibility of appetite and appetite-regulatory hormone responses to acute exercise and quantified the individual differences in responses. Methods: Fifteen healthy, recreationally active men completed two control (60-min resting) and two exercise (60-min fasted treadmill
running at 70% peak oxygen uptake) conditions in randomised sequences. Perceived appetite
and circulating concentrations of acylated ghrelin and total peptide YY (PYY) were
measured immediately before and after the interventions. Inter-individual differences were
explored by correlating the two sets of response differences between exercise and control
conditions. Within-participant covariate-adjusted linear mixed models were used to quantify
participant-by-condition interactions. Results: Compared with control, exercise suppressed
mean acylated ghrelin concentrations and appetite perceptions (all ES = 0.62 to 1.47, P <
0.001), and elevated total PYY concentrations (ES = 1.49, P < 0.001). For all variables, the
SD of the change scores was substantially greater in the exercise versus control conditions.
Moderate-to-large positive correlations were observed between the two sets of control
adjusted exercise responses for all variables (r = 0.54 to 0.82, P ≤ 0.036). After adjusting for
baseline measurements, participant-by-condition interactions were present for all variables (P
≤ 0.053). Conclusion: Our replicated cross-over study allowed, for the first time, the
interaction between participant and acute exercise response in appetite parameters to be
quantified. Even after adjustment for individual baseline measurements, participants
demonstrated individual differences in perceived appetite and hormone responses to acute
exercise bouts beyond any random within-subject variability over time.
AB - Purpose: Acute exercise transiently suppresses appetite, which coincides with alterations in
appetite-regulatory hormone concentrations. Individual variability in these responses is
suspected, but replicated trials are needed to quantify them robustly. We examined the reproducibility of appetite and appetite-regulatory hormone responses to acute exercise and quantified the individual differences in responses. Methods: Fifteen healthy, recreationally active men completed two control (60-min resting) and two exercise (60-min fasted treadmill
running at 70% peak oxygen uptake) conditions in randomised sequences. Perceived appetite
and circulating concentrations of acylated ghrelin and total peptide YY (PYY) were
measured immediately before and after the interventions. Inter-individual differences were
explored by correlating the two sets of response differences between exercise and control
conditions. Within-participant covariate-adjusted linear mixed models were used to quantify
participant-by-condition interactions. Results: Compared with control, exercise suppressed
mean acylated ghrelin concentrations and appetite perceptions (all ES = 0.62 to 1.47, P <
0.001), and elevated total PYY concentrations (ES = 1.49, P < 0.001). For all variables, the
SD of the change scores was substantially greater in the exercise versus control conditions.
Moderate-to-large positive correlations were observed between the two sets of control
adjusted exercise responses for all variables (r = 0.54 to 0.82, P ≤ 0.036). After adjusting for
baseline measurements, participant-by-condition interactions were present for all variables (P
≤ 0.053). Conclusion: Our replicated cross-over study allowed, for the first time, the
interaction between participant and acute exercise response in appetite parameters to be
quantified. Even after adjustment for individual baseline measurements, participants
demonstrated individual differences in perceived appetite and hormone responses to acute
exercise bouts beyond any random within-subject variability over time.
U2 - 10.1249/MSS.0000000000001504
DO - 10.1249/MSS.0000000000001504
M3 - Article
SN - 0195-9131
VL - 50
SP - 758
EP - 768
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
IS - 4
ER -