Investigation of a traumatic psychosis subgroup: a cluster analysis of an antipsychotic free cohort.

Lucy H. Stevens, Douglas Turkington, Laura Drage, Tony Morrison, Steven Muncer, Helen M. Spencer, Robert Dudley

Research output: Contribution to journalArticle

Abstract

Childhood trauma is linked to an increased risk of developing psychosis in adulthood. The extent and severity of trauma experienced is known to correlate with the intensity or presence of specific psychotic symptoms. The relative impact of types of abuse and neglect (sexual, physical, emotional) is unknown. Cluster analysis was used to create natural groupings of similarity based on Childhood Trauma Questionnaire Scores (CTQ) in a sub-sample of 51 anti-psychotic-free patients with diagnoses of Schizophrenia Spectrum Disorders from the ACTION trial. The derived clusters were compared on the Positive and Negative Syndrome Scale (PANSS) scores. Two clusters emerged: one characterized by abuse and the other by neglect. The abuse group was found to have significantly higher positive symptoms scores (p < 0.05). This is the first investigation of this concept in an un-medicated cohort that distinguished between trauma types using natural groupings in the data, and therefore, a more ecologically valid means of exploring the existence of a traumatic psychosis subgroup.

Original languageEnglish
Pages (from-to)298-307
Number of pages10
JournalPsychosis
Volume11
Issue number4
Early online date27 Jun 2019
DOIs
Publication statusPublished - 27 Jun 2019

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Antipsychotic Agents
Cluster Analysis
Wounds and Injuries
Sex Offenses
Psychotic Disorders
Schizophrenia
Neurocognitive Disorders

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Stevens, L. H., Turkington, D., Drage, L., Morrison, T., Muncer, S., Spencer, H. M., & Dudley, R. (2019). Investigation of a traumatic psychosis subgroup: a cluster analysis of an antipsychotic free cohort. Psychosis, 11(4), 298-307. https://doi.org/10.1080/17522439.2019.1628290
Stevens, Lucy H. ; Turkington, Douglas ; Drage, Laura ; Morrison, Tony ; Muncer, Steven ; Spencer, Helen M. ; Dudley, Robert. / Investigation of a traumatic psychosis subgroup: a cluster analysis of an antipsychotic free cohort. In: Psychosis. 2019 ; Vol. 11, No. 4. pp. 298-307.
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Stevens, LH, Turkington, D, Drage, L, Morrison, T, Muncer, S, Spencer, HM & Dudley, R 2019, 'Investigation of a traumatic psychosis subgroup: a cluster analysis of an antipsychotic free cohort.', Psychosis, vol. 11, no. 4, pp. 298-307. https://doi.org/10.1080/17522439.2019.1628290

Investigation of a traumatic psychosis subgroup: a cluster analysis of an antipsychotic free cohort. / Stevens, Lucy H.; Turkington, Douglas; Drage, Laura; Morrison, Tony; Muncer, Steven; Spencer, Helen M.; Dudley, Robert.

In: Psychosis, Vol. 11, No. 4, 27.06.2019, p. 298-307.

Research output: Contribution to journalArticle

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Stevens LH, Turkington D, Drage L, Morrison T, Muncer S, Spencer HM et al. Investigation of a traumatic psychosis subgroup: a cluster analysis of an antipsychotic free cohort. Psychosis. 2019 Jun 27;11(4):298-307. https://doi.org/10.1080/17522439.2019.1628290