Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma

Peixun Zhou, Alexander Newman, Filbert Adlar, Casey Broadbent, Alex E Blain, Amber Whitehead, Amy Hall, George Chagaluka, Elizabeth Molyneux, Simon Bailey, Chris M. Bacon, Simon Bomken, Vikki Rand

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Burkitt lymphoma (BL) is an aggressive mature B‐cell non‐Hodgkin lymphoma (B‐NHL) which consists of three subtypes: sporadic BL (sBL), endemic BL (eBL) and immuno‐deficiency related BL. Over 90% of children diagnosed with sBL in high‐income countries are successfully treated by current high‐intensity protocols. However, such intensive regimens are undeliverable in less well‐resourced settings. There is a need to identify markers to stratify low‐ and high‐risk patients and identify new therapeutic strategies. We have identified recurrent activating mutations of the transcription factor FOXO1 in both eBL and sBL. Similar mutations have been associated with poor outcome in diffuse large B cell lymphoma in adults, however the importance of FOXO1 has not been investigated in BL.
Original languageEnglish
Pages (from-to)40-40
JournalBritish Journal of Haematology
Volume182
Issue numberS1
DOIs
Publication statusPublished - 19 Sep 2018
EventSixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma - Rotterdam, Netherlands
Duration: 26 Sep 201829 Sep 2018
https://onlinelibrary.wiley.com/toc/13652141/2018/182/S1

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