Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma

Peixun Zhou; Alexander Newman; Filbert Adlar; Casey Broadbent; Alex E Blain; Amber Whitehead; Amy Hall; George Chagaluka; Elizabeth  Molyneux; Simon  Bailey; Chris M. Bacon; Simon  Bomken; Vikki Rand

Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma

Peixun Zhou, Alexander Newman, Filbert Adlar, Casey Broadbent, Alex E Blain, Amber Whitehead, Amy Hall, George Chagaluka, Elizabeth Molyneux, Simon Bailey, Chris M. Bacon, Simon Bomken, Vikki Rand

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Burkitt lymphoma (BL) is an aggressive mature B‐cell non‐Hodgkin lymphoma (B‐NHL) which consists of three subtypes: sporadic BL (sBL), endemic BL (eBL) and immuno‐deficiency related BL. Over 90% of children diagnosed with sBL in high‐income countries are successfully treated by current high‐intensity protocols. However, such intensive regimens are undeliverable in less well‐resourced settings. There is a need to identify markers to stratify low‐ and high‐risk patients and identify new therapeutic strategies. We have identified recurrent activating mutations of the transcription factor FOXO1 in both eBL and sBL. Similar mutations have been associated with poor outcome in diffuse large B cell lymphoma in adults, however the importance of FOXO1 has not been investigated in BL.

Original language	English
Pages (from-to)	40-40
Journal	British Journal of Haematology
Volume	182
Issue number	S1
Publication status	Published - 19 Sept 2018
Event	Sixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma - Rotterdam, Netherlands Duration: 26 Sept 2018 → 29 Sept 2018 https://onlinelibrary.wiley.com/toc/13652141/2018/182/S1

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https://onlinelibrary.wiley.com/doi/10.1111/bjh.15536

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@article{f89a2b89b88642cd97ac758c26e73585,

title = "Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma",

abstract = "Burkitt lymphoma (BL) is an aggressive mature B‐cell non‐Hodgkin lymphoma (B‐NHL) which consists of three subtypes: sporadic BL (sBL), endemic BL (eBL) and immuno‐deficiency related BL. Over 90% of children diagnosed with sBL in high‐income countries are successfully treated by current high‐intensity protocols. However, such intensive regimens are undeliverable in less well‐resourced settings. There is a need to identify markers to stratify low‐ and high‐risk patients and identify new therapeutic strategies. We have identified recurrent activating mutations of the transcription factor FOXO1 in both eBL and sBL. Similar mutations have been associated with poor outcome in diffuse large B cell lymphoma in adults, however the importance of FOXO1 has not been investigated in BL. ",

author = "Peixun Zhou and Alexander Newman and Filbert Adlar and Casey Broadbent and Blain, {Alex E} and Amber Whitehead and Amy Hall and George Chagaluka and Elizabeth Molyneux and Simon Bailey and Bacon, {Chris M.} and Simon Bomken and Vikki Rand",

year = "2018",

month = sep,

day = "19",

language = "English",

volume = "182",

pages = "40--40",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "S1",

note = "Sixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma ; Conference date: 26-09-2018 Through 29-09-2018",

url = "https://onlinelibrary.wiley.com/toc/13652141/2018/182/S1",

}

TY - JOUR

T1 - Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma

AU - Zhou, Peixun

AU - Newman, Alexander

AU - Adlar, Filbert

AU - Broadbent, Casey

AU - Blain, Alex E

AU - Whitehead, Amber

AU - Hall, Amy

AU - Chagaluka, George

AU - Molyneux, Elizabeth

AU - Bailey, Simon

AU - Bacon, Chris M.

AU - Bomken, Simon

AU - Rand, Vikki

PY - 2018/9/19

Y1 - 2018/9/19

N2 - Burkitt lymphoma (BL) is an aggressive mature B‐cell non‐Hodgkin lymphoma (B‐NHL) which consists of three subtypes: sporadic BL (sBL), endemic BL (eBL) and immuno‐deficiency related BL. Over 90% of children diagnosed with sBL in high‐income countries are successfully treated by current high‐intensity protocols. However, such intensive regimens are undeliverable in less well‐resourced settings. There is a need to identify markers to stratify low‐ and high‐risk patients and identify new therapeutic strategies. We have identified recurrent activating mutations of the transcription factor FOXO1 in both eBL and sBL. Similar mutations have been associated with poor outcome in diffuse large B cell lymphoma in adults, however the importance of FOXO1 has not been investigated in BL.

AB - Burkitt lymphoma (BL) is an aggressive mature B‐cell non‐Hodgkin lymphoma (B‐NHL) which consists of three subtypes: sporadic BL (sBL), endemic BL (eBL) and immuno‐deficiency related BL. Over 90% of children diagnosed with sBL in high‐income countries are successfully treated by current high‐intensity protocols. However, such intensive regimens are undeliverable in less well‐resourced settings. There is a need to identify markers to stratify low‐ and high‐risk patients and identify new therapeutic strategies. We have identified recurrent activating mutations of the transcription factor FOXO1 in both eBL and sBL. Similar mutations have been associated with poor outcome in diffuse large B cell lymphoma in adults, however the importance of FOXO1 has not been investigated in BL.

M3 - Meeting Abstract

SN - 0007-1048

VL - 182

SP - 40

EP - 40

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - S1

T2 - Sixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma

Y2 - 26 September 2018 through 29 September 2018

ER -

Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma

Abstract

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