TY - JOUR
T1 - Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study
AU - Patel, Jeetesh V.
AU - Chackathayil, Julia
AU - Gammon, Brian
AU - Tracey, Inessa
AU - Lovick, Adam
AU - Gill, Paramjit S.
AU - Banerjee, Amitava
AU - Scarff, Charlotte A.
AU - Scrivens, James
AU - Lip, Gregory Y.H.
AU - Hughes, Elizabeth A.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron.Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P < 0.001), as were subfractionated lipoprotein concentrations of iron (P < 0.001). Patients with haemoglobin disorders had greater CIMT (0.75 vs. 0.65 mm, P = 0.008), and lower HDL cholesterol (0.78 vs. 1.03 mmol/l, P = 0.003). These preliminary data suggest that haemoglobin disorders contribute to atherosclerotic disease in South Asians and further research is warranted.
AB - The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron.Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P < 0.001), as were subfractionated lipoprotein concentrations of iron (P < 0.001). Patients with haemoglobin disorders had greater CIMT (0.75 vs. 0.65 mm, P = 0.008), and lower HDL cholesterol (0.78 vs. 1.03 mmol/l, P = 0.003). These preliminary data suggest that haemoglobin disorders contribute to atherosclerotic disease in South Asians and further research is warranted.
UR - http://www.scopus.com/inward/record.url?scp=84871385338&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2012.09.017
DO - 10.1016/j.atherosclerosis.2012.09.017
M3 - Article
C2 - 23141472
AN - SCOPUS:84871385338
SN - 0021-9150
VL - 226
SP - 198
EP - 200
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -