Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study

Jeetesh V. Patel, Julia Chackathayil, Brian Gammon, Inessa Tracey, Adam Lovick, Paramjit S. Gill, Amitava Banerjee, Charlotte A. Scarff, James Scrivens, Gregory Y.H. Lip, Elizabeth A. Hughes

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    Abstract

    The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron.Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P < 0.001), as were subfractionated lipoprotein concentrations of iron (P < 0.001). Patients with haemoglobin disorders had greater CIMT (0.75 vs. 0.65 mm, P = 0.008), and lower HDL cholesterol (0.78 vs. 1.03 mmol/l, P = 0.003). These preliminary data suggest that haemoglobin disorders contribute to atherosclerotic disease in South Asians and further research is warranted.

    Original languageEnglish
    Pages (from-to)198-200
    Number of pages3
    JournalAtherosclerosis
    Volume226
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2013

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    Patel, J. V., Chackathayil, J., Gammon, B., Tracey, I., Lovick, A., Gill, P. S., Banerjee, A., Scarff, C. A., Scrivens, J., Lip, G. Y. H., & Hughes, E. A. (2013). Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study. Atherosclerosis, 226(1), 198-200. https://doi.org/10.1016/j.atherosclerosis.2012.09.017