Lack of replication for the myosin-18B association with mathematical ability in independent cohorts.

K. A. Pettigrew, S. F. Fajutrao Valles , K. Moll, K. Northstone, S. Ring, C. Pennell, C. Wang, R. Leavett, M.E. Hayiou-Thomas, P. Thompson, N. H. Simpson, S. E. Fisher, A. J. O. Whitehouse, M. J. Snowling, D.F. Newbury, S. Paracchini

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Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalGenes, brain, and behavior
Publication statusPublished - 1 Apr 2015
Externally publishedYes


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