TY - JOUR
T1 - Lack of replication for the myosin-18B association with mathematical ability in independent cohorts.
AU - Pettigrew, K. A.
AU - Fajutrao Valles , S. F.
AU - Moll, K.
AU - Northstone, K.
AU - Ring, S.
AU - Pennell, C.
AU - Wang, C.
AU - Leavett, R.
AU - Hayiou-Thomas, M.E.
AU - Thompson, P.
AU - Simpson, N. H.
AU - Fisher, S. E.
AU - Whitehouse, A. J. O.
AU - Snowling, M. J.
AU - Newbury, D.F.
AU - Paracchini, S.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.
AB - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.
UR - http://europepmc.org/abstract/med/25778778
U2 - 10.1111/gbb.12213
DO - 10.1111/gbb.12213
M3 - Article
C2 - 25778778
SP - 369
EP - 376
JO - Genes, brain, and behavior
JF - Genes, brain, and behavior
ER -