Measuring adaptation to extreme environments with a multi-omic approach

Claudio Angione, Sandra Pucciarelli, Basarbatu Can, Marina Lotti, Alessio Mancini, Andrea Telatin

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    During the past decade, more than 4000 organisms have been subjects of
    genome-sequencing projects. This has enabled the retrieval of information such as evo-
    lutionary relationships among all living organisms, and the understanding of complex
    phenomena, including evolution, adaptation, and ecology. Bioinformatics tools have
    allowed us to perform genome annotation, cross-comparison, and to understand the
    metabolic potential of living organisms. In the last few years, research in bioinfor-
    matics started to evolve from the analysis of genomic sequences and structural biology
    problems, to the analysis of complex post-genomic interaction networks. The main out-
    come of this effort has been the creation of: (i) databases and ontologies of protein
    class and cell components; (ii) repositories of models of cell processes, through the def-
    inition of common exchange formats such as the Systems Biology Markup Language
    (SBML); (iii) simulation tools; (iv) Multi-scale modeling (micro-macro biology). How-
    ever, the following questions remain open: what is the real functioning scheme of the
    cell? What is the metabolic influence of changes in gene expression? How to understand
    the metabolic interactions among living organisms in a ecosystem? How to understand
    evolutionary mechanisms of adaptation? Here, we describe a pipeline that summarizes
    the methodologies recently proposed to address these questions.
    Original languageEnglish
    Title of host publicationComputational Intelligence Methods for Bioinformatics and Biostatistics
    Place of PublicationNaples, Italy
    PublisherDepartment of Informatics, University of Salerno and Istituto pe r le Applicazioni del Calcolo CNR
    ISBN (Electronic)9788890643798
    Publication statusPublished - 10 Sep 2015
    Event12th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics - CNR Research Area, Naples, Italy
    Duration: 10 Sep 201512 Sep 2015
    Conference number: 12

    Conference

    Conference12th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics
    Abbreviated titleCIBB 2015
    CountryItaly
    CityNaples
    Period10/09/1512/09/15

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