Mechanical Influence of Tissue Scaffolding Design with Different Geometries using Finite Element Study

Xinyi An, Perk Lin Chong, Iman Zohourkari , Sandipan Roy, Ali Merdji, Constance Linda Gnanasagaran, Foad Faraji, Lip Kean Moey, Mohammad Hossein Yazdi

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Abstract

The mechanical properties of tissue scaffolds are essential in providing stability for tissue repair and growth. Thus, the ability of scaffolds to withstand specific loads is crucial for scaffold design. Most research on scaffold pores focuses on grids with pore size and gradient structure, and many research models are based on scaffolding with vertically arranged holes. However, little attention is paid to the influence of the distribution of holes on the mechanical properties of the scaffold. To address this
gap, this research investigates the effect of pore distribution on the mechanical properties of tissue scaffolds. The study involves four types of scaffold designs with regular and staggered pore arrangements and porosity ranging from 30% to 80%. Finite element analysis (FEA) was used to compare the mechanical properties of different scaffold designs,
with von-Mises stress distribution maps generated for each scaffold. The results show that scaffolds with regular vertical holes exhibit a more uniform stress distribution and better mechanical performance than those with irregular holes. In contrast, the scaffold with a staggered arrangement of holes had a higher probability of stress concentration.
The study emphasized the importance of balancing porosity and strength in scaffold design.
Original languageEnglish
Number of pages9
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
DOIs
Publication statusPublished - 21 Jul 2023

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© IMechE 2023.

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