TY - JOUR
T1 - Metal-based ethanolamine-derived compounds: a note on their synthesis, characterization and bioactivity
AU - Amjad, Muhammad
AU - Sumrra, S. H. (Sajjad)
AU - Akram, Muhammad Safwan
AU - Chohan, Zahid H.
PY - 2016/8/24
Y1 - 2016/8/24
N2 - Metal-based ethanolamines, (L1)–(L4) coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals in
1:2 (metal:ligand) molar ratio to produce new compounds have been reported. These
compounds were screened for their bactericidal/fungicidal activity against a number of
bacterial (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi,
Staphylococcus aureus and Bacillus subtilis) and fungal strains (Trichophyton longifusus,
Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata)
alongside against a shrimp species known as Artemia salina. The screening results indicated
that metal complexes have significantly higher activity than uncomplexed ligands against one
or more bacterial/fungal species due to chelation. The ligand (L4) displayed good bacterial and
fungal activity as compared to other ligands. The antibacterial results revealed that the Zn(II)
complex (16) of (L4) was found to be the most active complex and Co(II) complex (14) of the
same ligand (L4), demonstrated the highest antifungal activity.
AB - Metal-based ethanolamines, (L1)–(L4) coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals in
1:2 (metal:ligand) molar ratio to produce new compounds have been reported. These
compounds were screened for their bactericidal/fungicidal activity against a number of
bacterial (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi,
Staphylococcus aureus and Bacillus subtilis) and fungal strains (Trichophyton longifusus,
Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata)
alongside against a shrimp species known as Artemia salina. The screening results indicated
that metal complexes have significantly higher activity than uncomplexed ligands against one
or more bacterial/fungal species due to chelation. The ligand (L4) displayed good bacterial and
fungal activity as compared to other ligands. The antibacterial results revealed that the Zn(II)
complex (16) of (L4) was found to be the most active complex and Co(II) complex (14) of the
same ligand (L4), demonstrated the highest antifungal activity.
U2 - 10.1080/14756366.2016.1220375
DO - 10.1080/14756366.2016.1220375
M3 - Article
SN - 1475-6366
SP - -
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
ER -