Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target

Panagiota S. Filippou, George Karagiannis, Anastasia Constantinidou

Research output: Contribution to journalArticle

Abstract

Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Several studies have investigated the role of midkine as a cancer biomarker for the detection, prognosis, and management of cancer, as well as for monitoring the response to cancer treatment. Moreover, several efforts are also being made to elucidate its underlying mechanisms in therapeutic resistance and immunomodulation within the tumor microenvironment. We hereby summarize the current knowledge on midkine expression and function in cancer development and progression, and highlight its promising potential as a cancer biomarker and as a future therapeutic target in personalized cancer medicine.
Original languageEnglish
JournalOncogene
DOIs
Publication statusPublished - 4 Dec 2019

Fingerprint

Intercellular Signaling Peptides and Proteins
Neoplasms
Tumor Biomarkers
Therapeutics
Precision Medicine
Tumor Microenvironment
Immunomodulation
Tretinoin
Embryonic Development
Heparin
midkine
Cell Survival
Homeostasis
Neoplasm Metastasis
Growth
Genes

Cite this

@article{3a1cd7093dea4e8d92a1615b5e0fb5da,
title = "Midkine (MDK) growth factor:: a key player in cancer progression and a promising therapeutic target",
abstract = "Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Several studies have investigated the role of midkine as a cancer biomarker for the detection, prognosis, and management of cancer, as well as for monitoring the response to cancer treatment. Moreover, several efforts are also being made to elucidate its underlying mechanisms in therapeutic resistance and immunomodulation within the tumor microenvironment. We hereby summarize the current knowledge on midkine expression and function in cancer development and progression, and highlight its promising potential as a cancer biomarker and as a future therapeutic target in personalized cancer medicine.",
author = "Filippou, {Panagiota S.} and George Karagiannis and Anastasia Constantinidou",
year = "2019",
month = "12",
day = "4",
doi = "10.1038/s41388-019-1124-8",
language = "English",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",

}

Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target. / Filippou, Panagiota S.; Karagiannis, George ; Constantinidou, Anastasia.

In: Oncogene, 04.12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Midkine (MDK) growth factor:

T2 - a key player in cancer progression and a promising therapeutic target

AU - Filippou, Panagiota S.

AU - Karagiannis, George

AU - Constantinidou, Anastasia

PY - 2019/12/4

Y1 - 2019/12/4

N2 - Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Several studies have investigated the role of midkine as a cancer biomarker for the detection, prognosis, and management of cancer, as well as for monitoring the response to cancer treatment. Moreover, several efforts are also being made to elucidate its underlying mechanisms in therapeutic resistance and immunomodulation within the tumor microenvironment. We hereby summarize the current knowledge on midkine expression and function in cancer development and progression, and highlight its promising potential as a cancer biomarker and as a future therapeutic target in personalized cancer medicine.

AB - Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Several studies have investigated the role of midkine as a cancer biomarker for the detection, prognosis, and management of cancer, as well as for monitoring the response to cancer treatment. Moreover, several efforts are also being made to elucidate its underlying mechanisms in therapeutic resistance and immunomodulation within the tumor microenvironment. We hereby summarize the current knowledge on midkine expression and function in cancer development and progression, and highlight its promising potential as a cancer biomarker and as a future therapeutic target in personalized cancer medicine.

UR - http://www.scopus.com/inward/record.url?scp=85076088585&partnerID=8YFLogxK

U2 - 10.1038/s41388-019-1124-8

DO - 10.1038/s41388-019-1124-8

M3 - Article

JO - Oncogene

JF - Oncogene

SN - 0950-9232

ER -