Morphometry analysis of neuronal and glial cell pathology in the dorsolateral prefrontal cortex in late-life depression

Ahmad Khundakar, Christopher Morris, Arthur Oakley, William McMeekin, Alan J. Thomas

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    Background: Late-life depression has been associated with cerebrovascular disease and especially with ischaemic white matter hyperintensities on magnetic resonance imaging. Neuroimaging and morphometric studies have identified abnormalities in the dorsolateral prefrontal cortex. Aims: To examine glial and neuronal density and neuronal volume in the dorsolateral prefrontal cortex in late-life major depression. Method: We used the disector and nucleator methods to estimate neuronal density and volume and glial density of cells in the dorsolateral prefrontal cortex in a post-mortem study of 17 individuals with late-life major depression and 10 age-matched controls. Results: We found a reduction in the volume of pyramidal neurones in the whole cortex, which was also present in layer 3 and more markedly in layer 5. There were no comparable changes in non-pyramidal neurones and no glial differences. Conclusions: Overall, we found a decrease in pyramidal neuronal size in the dorsolateral prefrontal cortex in late-life depression.

    Original languageEnglish
    Pages (from-to)163-169
    Number of pages7
    JournalBritish Journal of Psychiatry
    Volume195
    Issue number2
    DOIs
    Publication statusPublished - 1 Aug 2009

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