Multifunctional Biocompatible Fluorescent Carboxymethyl Cellulose Nanoparticles

Ravindran Girija Aswathy, Balasubramanian Sivakumar, Dhandayuthapani Brahatheeswaran, Sreejith Raveendran, Tomofomi Ukai, Takahiro Fukuda, Yasuhiko Yoshida, Toru Maekawa, Dasappan Nair Sakthikumar

Research output: Contribution to journalArticlepeer-review


A multifunctional nanoparticle based on Carboxymethyl cellulose was developed. Folate group was attached to nanoparticle for specific recognition of cancerous cells and 5FU was encapsulated for delivering cytotoxicity. The whole system
was able to track by the semiconductor quantum dots that were attached to the nanoparticle. The multifunctional
nanoparticle was characterized by UV-VIS spectra, PL spectra, FTIR, TEM, SEM etc and was targeted to human breast
cancer cell, MCF7. The biocompatibility of nanoparticle without drug and cytotoxicity rendered by nanoparticle with
drug was studied with MCF7 and L929 cell lines. The epifluorescent images suggest that the folate-conjugated nanoparticles were more internalized by folate receptor positive cell line, MCF7 than the noncancerous L929 cells.
Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalJournal of Biomaterials and Nanobiotechnology
Publication statusPublished - 10 Mar 2012


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