Non-Invasive cardiac evaluation in heart failure patients using magnetic resonance imaging: A feasibility study

Stephanie M. Shors, William G. Cotts, Biljana Pavlovic-Surjancev, Mihai Gheorghiade, James C. Carr, Richard M. McCarthy, Scott F. Pereles, Paul J. Finn

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    4 Citations (Scopus)


    Background: To assess the feasibility of a fast, flow-insensitive magnetic resonance imaging (MRI) protocol in heart failure patients for the evaluation of cardiac function, cardiovascular anatomy, and myocardial viability. Methods and results: Thirty-two consecutive patients with left ventricular (LV) systolic dysfunction and 13 control subjects were prospectively evaluated with MRI. The exam consisted of cine imaging with a steady-state free precession sequence, followed by time-resolved, three-dimensional angiography and delayed, contrast-enhanced imaging. Multiple LV parameters were evaluated, and the heart failure and control results were compared. In 12 patients, MRI-determined ejection fractions were compared to echocardiographic values. Additionally, a qualitative analysis of the cine images was performed. The cardiac MR evaluation yielded diagnostic-quality images in all subjects. Mean imaging time was 37 min. MRI demonstrated significant differences between the heart failure and control subjects in all parameters assessed (p< 0.05). MRI-determined ejection fractions correlated strongly with echocardiographic values (R= 0.75), although the limits of agreement were wide (17.3%-18.3%). Conclusions: Using fast, flow-insensitive imaging techniques, MRI is feasible in heart failure for the derivation of more independent indices of cardiac status than any other non-invasive test. Although further investigation is warranted, MRI may prove uniquely helpful in heart failure diagnosis and management.

    Original languageEnglish
    Pages (from-to)265-273
    Number of pages9
    JournalHeart Failure Reviews
    Issue number4
    Publication statusPublished - 1 Dec 2005


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