On-line reaction monitoring by mass spectrometry, modern approaches for the analysis of chemical reactions

Andrew Ray, Tony Bristow, Chris Whitmore, Jackie Mosely

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


The application of on-line mass spectrometry for direct analysis of chemical and other types of process continues to grow in importance and impact. The ability of the technique to characterize many aspects of a chemical reaction such as product and impurity formation, along with reactant consumption in a single experiment is key to its adoption and development. Innovations in ionization techniques and mass spectrometry instrumentation are enabling this adoption. An increasing range of ambient ionization techniques make on-line mass spectrometry applicable to a large range of chemistries. The academic development and commercialization of small footprint portable/transportable mass spectrometers is providing technology that can be positioned with any process under investigation. These developments, coupled with research into new ways of sampling representatively from both the condensed and gaseous phases, are positioning mass spectrometry as an essential technology for on-line process optimization, understanding and intelligent control. It is recognized that quantitative capability of mass spectrometry in this application can cause some resistance to its adoption, but research activities to tackle this limitation are on-going.

Original languageEnglish
Pages (from-to)565-579
Number of pages15
JournalMass Spectrometry Reviews
Issue number4
Publication statusPublished - 1 Jul 2018

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