Abstract
Background
The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer.
Methods
The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease-free survival (DFS), and overall survival (OS) rates were calculated.
Results
The pooled mean estimates were: local control rate at 24 months after first TLM (n = 249), 56.9% (95% confidence interval [CI], 47.4–66.1); local control after repeat TLM (n = 186), 63.8% (95% CI, 57.1–70.2); DFS (n = 174), 70.9% (95% CI, 60.8–80); and OS (n = 276), 74.8% (95% CI, 68.2–80.9). Pooled mean laryngeal preservation (n = 286) was 72.3% (95% CI, 68.4–76.1).
Conclusion
TLM is oncologically sound in the salvage setting with high larynx-preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques
The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer.
Methods
The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease-free survival (DFS), and overall survival (OS) rates were calculated.
Results
The pooled mean estimates were: local control rate at 24 months after first TLM (n = 249), 56.9% (95% confidence interval [CI], 47.4–66.1); local control after repeat TLM (n = 186), 63.8% (95% CI, 57.1–70.2); DFS (n = 174), 70.9% (95% CI, 60.8–80); and OS (n = 276), 74.8% (95% CI, 68.2–80.9). Pooled mean laryngeal preservation (n = 286) was 72.3% (95% CI, 68.4–76.1).
Conclusion
TLM is oncologically sound in the salvage setting with high larynx-preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques
| Original language | English |
|---|---|
| Pages (from-to) | 280-285 |
| Journal | Head and Neck |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |