Definition: Multiple long-term conditions such as the simultaneous prevalence of obesity, diabetes and cardiovascular disease are becoming increasingly prevalent globally with major consequences of morbidity, mortality and health economy. Lifestyle preventative approaches, especially combining nutrition and physical activity behavioral components, are essential in preventing multiple long-term conditions. However, funded research programs often focus on a single disease or a condition rather than a cluster of conditions. This entry addresses how lifestyle components, especially exercise and nutrition, could target multiple risk reductions associated with preventing multiple long-term conditions, especially diabetes and cardiovascular disease. Innovative exercise prescription should include different intensity-based approaches, which may include intense forms of exercise, but one size does not fit all. Nutritional intake guidelines can also be individualized to target multiple long-term conditions, which all contribute to informing better public health preventative policies.