Paper-based microfluidic point-of-care diagnostic devices

Ali Kemal Yetisen, Muhammad Safwan Akram, Christopher R. Lowe

Research output: Contribution to journalReview article

856 Citations (Scopus)

Abstract

Dipstick and lateral-flow formats have dominated rapid diagnostics over the last three decades. These formats gained popularity in the consumer markets due to their compactness, portability and facile interpretation without external instrumentation. However, lack of quantitation in measurements has challenged the demand of existing assay formats in consumer markets. Recently, paper-based microfluidics has emerged as a multiplexable point-of-care platform which might transcend the capabilities of existing assays in resource-limited settings. However, paper-based microfluidics can enable fluid handling and quantitative analysis for potential applications in healthcare, veterinary medicine, environmental monitoring and food safety. Currently, in its early development stages, paper-based microfluidics is considered a low-cost, lightweight, and disposable technology. The aim of this review is to discuss: (1) fabrication of paper-based microfluidic devices, (2) functionalisation of microfluidic components to increase the capabilities and the performance, (3) introduction of existing detection techniques to the paper platform and (4) exploration of extracting quantitative readouts via handheld devices and camera phones. Additionally, this review includes challenges to scaling up, commercialisation and regulatory issues. The factors which limit paper-based microfluidic devices to become real world products and future directions are also identified.

Original languageEnglish
Pages (from-to)2210-2251
Number of pages42
JournalLab on a Chip
Volume13
Issue number12
DOIs
Publication statusPublished - 21 Jun 2013

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Point-of-Care Systems
Microfluidics
Lab-On-A-Chip Devices
Equipment and Supplies
Assays
Veterinary medicine
Veterinary Medicine
Food Safety
Environmental Monitoring
Food safety
Technology
Delivery of Health Care
Costs and Cost Analysis
Cameras
Fabrication
Fluids
Monitoring
Chemical analysis

Cite this

Yetisen, Ali Kemal ; Akram, Muhammad Safwan ; Lowe, Christopher R. / Paper-based microfluidic point-of-care diagnostic devices. In: Lab on a Chip. 2013 ; Vol. 13, No. 12. pp. 2210-2251.
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Paper-based microfluidic point-of-care diagnostic devices. / Yetisen, Ali Kemal; Akram, Muhammad Safwan; Lowe, Christopher R.

In: Lab on a Chip, Vol. 13, No. 12, 21.06.2013, p. 2210-2251.

Research output: Contribution to journalReview article

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