PEG coated biocompatible cadmium chalcogenide quantum dots for targeted imaging of cancer cells

Aby Cheruvathoor Poulose, Srivani Veeranarayanan, M. Sheikh Mohamed, Sreejith Raveendran, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer stands as a leading cause of mortality worldwide and diagnostics of cancer still faces drawbacks. Optical imaging of cancer would allow early diagnosis, evaluation of disease progression and therapy efficiency. To that aim, we have developed highly biocompatible PEG functionalized cadmium chalcogenide based three differently luminescent quantum dots (QDs) (CdS, CdSe and CdTe). Folate targeting scheme was utilized for targeting cancer cell line, MCF-7. We demonstrate the biocompatibility, specificity and efficiency of our nanotool in detection of cancer cells sparing normal cell lines with retained fluorescence of functionalized QDs as parental counterpart. This is the first time report of utilizing three differently fluorescent QDs and we have detailed about the internalization of these materials and time dependent saturation of targeting schemes. We present here the success of utilizing our biocompatible imaging tool for early diagnosis of cancer.

Original languageEnglish
Pages (from-to)931–944
JournalJournal of Fluorescence
Volume22
Early online date8 Jan 2012
DOIs
Publication statusPublished - 31 May 2012

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