Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches

Andrew T. Reid, Punnam Chander Veerati, Reinoud Gosens, Nathan W. Bartlett, Peter A. Wark, Chris L. Grainge, Stephen M. Stick, Anthony Kicic, Fatemeh Moheimani, Philip M. Hansbro, Darryl A. Knight

    Research output: Contribution to journalReview article

    2 Citations (Scopus)

    Abstract

    Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.

    Original languageEnglish
    Pages (from-to)155-169
    Number of pages15
    JournalPharmacology and Therapeutics
    Volume185
    DOIs
    Publication statusPublished - 1 May 2018

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  • Cite this

    Reid, A. T., Veerati, P. C., Gosens, R., Bartlett, N. W., Wark, P. A., Grainge, C. L., Stick, S. M., Kicic, A., Moheimani, F., Hansbro, P. M., & Knight, D. A. (2018). Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches. Pharmacology and Therapeutics, 185, 155-169. https://doi.org/10.1016/j.pharmthera.2017.12.009