Persistent induction of goblet cell differentiation in the airways

Therapeutic approaches

Andrew T. Reid, Punnam Chander Veerati, Reinoud Gosens, Nathan W. Bartlett, Peter A. Wark, Chris L. Grainge, Stephen M. Stick, Anthony Kicic, Fatemeh Moheimani, Philip M. Hansbro, Darryl A. Knight

Research output: Contribution to journalReview articleResearchpeer-review

2 Citations (Scopus)

Abstract

Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.

Original languageEnglish
Pages (from-to)155-169
Number of pages15
JournalPharmacology and Therapeutics
Volume185
DOIs
Publication statusPublished - 1 May 2018

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Goblet Cells
Mucus
Cell Differentiation
Therapeutics
Chronic Disease
Pathology
Cytokines

Cite this

Reid, A. T., Veerati, P. C., Gosens, R., Bartlett, N. W., Wark, P. A., Grainge, C. L., ... Knight, D. A. (2018). Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches. Pharmacology and Therapeutics, 185, 155-169. https://doi.org/10.1016/j.pharmthera.2017.12.009
Reid, Andrew T. ; Veerati, Punnam Chander ; Gosens, Reinoud ; Bartlett, Nathan W. ; Wark, Peter A. ; Grainge, Chris L. ; Stick, Stephen M. ; Kicic, Anthony ; Moheimani, Fatemeh ; Hansbro, Philip M. ; Knight, Darryl A. / Persistent induction of goblet cell differentiation in the airways : Therapeutic approaches. In: Pharmacology and Therapeutics. 2018 ; Vol. 185. pp. 155-169.
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abstract = "Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.",
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Reid, AT, Veerati, PC, Gosens, R, Bartlett, NW, Wark, PA, Grainge, CL, Stick, SM, Kicic, A, Moheimani, F, Hansbro, PM & Knight, DA 2018, 'Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches', Pharmacology and Therapeutics, vol. 185, pp. 155-169. https://doi.org/10.1016/j.pharmthera.2017.12.009

Persistent induction of goblet cell differentiation in the airways : Therapeutic approaches. / Reid, Andrew T.; Veerati, Punnam Chander; Gosens, Reinoud; Bartlett, Nathan W.; Wark, Peter A.; Grainge, Chris L.; Stick, Stephen M.; Kicic, Anthony; Moheimani, Fatemeh; Hansbro, Philip M.; Knight, Darryl A.

In: Pharmacology and Therapeutics, Vol. 185, 01.05.2018, p. 155-169.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Persistent induction of goblet cell differentiation in the airways

T2 - Therapeutic approaches

AU - Reid, Andrew T.

AU - Veerati, Punnam Chander

AU - Gosens, Reinoud

AU - Bartlett, Nathan W.

AU - Wark, Peter A.

AU - Grainge, Chris L.

AU - Stick, Stephen M.

AU - Kicic, Anthony

AU - Moheimani, Fatemeh

AU - Hansbro, Philip M.

AU - Knight, Darryl A.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.

AB - Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.

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U2 - 10.1016/j.pharmthera.2017.12.009

DO - 10.1016/j.pharmthera.2017.12.009

M3 - Review article

VL - 185

SP - 155

EP - 169

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

SN - 0163-7258

ER -