Potent antitrypanosomal activities of 3-aminosteroids against African trypanosomes: investigation of cellular effects and of cross-resistance with existing drugs. Molecules

Keyphrases

• African Trypanosomes 100%
• Cross-resistance 100%
• Cellular Effects 100%
• Antitrypanosomal Activity 100%
• Aminosteroid 100%
• Existing Drugs 100%
• IC50 33%
• In Vitro Activity 33%
• Trypanocidal Activity 33%
• Trypanocides 33%
• Trypanosoma Congolense 33%
• Brucei 33%
• Mammalian Cells 16%
• Exposure Time 16%
• Selectivity Index 16%
• Non-associated 16%
• Further Development 16%
• Resistant Strains 16%
• Adenosine Triphosphate 16%
• Human African Trypanosomiasis 16%
• Trypanosoma Brucei 16%
• Mode of Action 16%
• Safe Drugs 16%
• Pentamidine 16%
• Savannah 16%
• Growth Pattern 16%
• Trypanosome 16%
• Bloodstream 16%
• Purified Compounds 16%
• Mitochondrial Membrane Depolarization 16%
• Drug-resistant Cancer Cell Lines 16%
• G2-M Cell Cycle Arrest 16%
• Membrane Permeabilization 16%
• Mitochondrial Accumulation 16%
• Resistant Cells 16%
• Affordable Drugs 16%
• L6 Myoblasts 16%
• Diminazene Aceturate 16%
• Growth Arrest 16%
• Veterinary Drugs 16%
• Low Selectivity 16%
• Trypomastigote 16%
• Resazurin 16%
• Cell Viability Assay 16%
• Potent Drugs 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Trypanosoma 100%
• Cross-Resistance 100%
• Antitrypanosomal 100%
• IC50 66%
• Antitrypanosomal Agent 66%
• Adenosine Triphosphate 33%
• Nagana 33%
• Trypanosoma Brucei Brucei 33%
• Pentamidine 33%
• Cell Viability 33%
• Viability Assay 33%
• Growth Disorder 33%
• Diminazene Aceturate 33%
• Resazurin 33%
• Trypomastigote 33%
• Veterinary Drug 33%

Immunology and Microbiology

• Wild Type 100%
• Trypanosoma 100%
• Cross-Resistance 100%
• IC50 66%
• Cell Viability 33%
• Trypanosoma Brucei Brucei 33%
• Mitochondrial Membrane 33%
• Myoblast 33%
• Selectivity Index 33%
• Pentamidine 33%
• Trypomastigote 33%
• Cell Cycle Arrest 33%
• Multidrug-Resistant Cell Line 33%
• Cell Cycle Checkpoint 33%