Predicting the outcome of prostatectomy using noninvasive bladder pressure and urine flow measurements.

Christopher Harding, Wendy Robson, Michael Drinnan, Mustafa Sajeel, Peter Ramsden, Clive Griffiths, Robert Pickard

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives
To determine whether categorisation of bladder outlet obstruction (BOO) using measurements of bladder pressure and urine flow obtained by a novel noninvasive medical device (the penile cuff test) improves prediction of outcome from endoscopic prostatectomy (TURP).

Methods
A consecutive cohort of 208 men undergoing TURP following standard assessment in our institution was recruited, and 179 (86%) completed the protocol. Each subject underwent a penile cuff test prior to surgery; outcome was assessed by change in IPSS at 4 mo. The proportion of men with good outcome (>50% reduction in IPSS) was compared according to categorisation by noninvasive bladder pressure and urine flow measurements.

Results
The cuff test was completed by 93% of men with 2% experiencing an adverse event. Men categorised as having BOO by the test (37% of total) had an 87% chance of a good outcome from TURP (p < 0.01), whilst of those deemed not obstructed (19% of total) 56% experienced good outcome (p < 0.01). For the remaining men not categorised in these two groups, 77% had good outcome, which was identical to the result of the cohort as a whole (77%, p = NS).

Conclusions
Urodynamic categorisation using measurements obtained by the noninvasive penile cuff test improves prediction of outcome for men with LUTS undergoing TURP. This finding together with the ease and acceptability of the test suggest its suitability for office-based clinical use to assist men and their physicians in the selection for surgical treatment for relief of LUTS.
Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalEuropean Urology
Volume52
Issue number1
Early online date13 Nov 2006
DOIs
Publication statusPublished - 1 Jul 2007
Externally publishedYes

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